Synthesis and pharmacological activities of some 3-substituted thienopyrimidin-4-one-2-thiones was written by Cannito, A.;Perrissin, M.;Luu Duc, Cuong;Huguet, F.;Gaultier, C.;Narcisse, G.. And the article was included in European Journal of Medicinal Chemistry in 1990.COA of Formula: C12H17NO2S The following contents are mentioned in the article:
The condensation of substituted 2-amino-3-carbethoxythiophenes with Me, Et and Ph isothiocyanate yields the corresponding thienylthioureas which cyclize in EtOH saturated with dry hydrochloric acid to form 3-substituted thieno[2,3-d]pyrimidin-4(3H)-one-2-thiones. Thirty-five compounds, 21 thienylthioureas and 14 thienopyrimidin-4-one-2-thiones, have been screened for their analgesic and antiinflammatory activities. The i.p. administration of these products at a dose of 1000 mg/kg shows that they are not toxic (one excepted). Some compounds show analgesic and antiinflammatory activities equivalent to those of acetylsalicylic acid. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9COA of Formula: C12H17NO2S).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C12H17NO2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem