Synthesis Characterization and In Vitro Antibacterial Activity of the N-Substituted Bis-Pyrazoline Derivative as Polycyclic Aromatic Compounds was written by Aqlan, Faisal M.. And the article was included in Polycyclic Aromatic Compounds in 2022.Reference of 638-02-8 The following contents are mentioned in the article:
N-substituted bis-pyrazolines I [R = 4-MeC6H4NH, 2-ClC6H4NH, 4-O2NC6H4NH, 2,4-F2C6H3NH, 2,6-F2C6H3NH] were synthesized by the reaction of bis-chalcone with N-substituted thiosemicarbazide derivatives under basic conditions. The bis-chalcone was synthesized by the reaction of 1-(2,5-dimethylthiophen-3-yl)ethan-1-one with terephthalaldehyde under basic condition. The in vitro antibacterial activity of I was estimated against two Gram-pos. and two Gram-neg. bacterial strains by the disk diffusion method and min. inhibitory concentration (MIC) method and the results were compared with standard drug Amoxicillin. The structure-activity relationship showed that I (R = 2-ClC6H4NH) was more active than standard drug Amoxicillin. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 638-02-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem