Day: November 21, 2022

Lyu, Yan published the artcileA Photolabile Semiconducting Polymer Nanotransducer for Near-Infrared Regulation of CRISPR/Cas9 Gene Editing, COA of Formula: C21H26Br4S2, the publication is Angewandte Chemie, International Edition (2019), 58(50), 18197-18201, database is CAplus and MEDLINE.

Noninvasive regulation of CRISPR/Cas9 gene editing is conducive to understanding of gene function and development of gene therapy; however, it remains challenging. Herein, a photolabile semiconducting polymer nanotransducer (pSPN) is synthesized to act as the gene vector to deliver CRISPR/Cas9 plasmids into cells and also as the photoregulator to remotely activate gene editing. pSPN comprises a ¹O₂-generating backbone grafted with polyethylenimine brushes through ¹O₂-cleavable linkers. NIR photoirradiation spontaneously triggers the cleavage of gene vectors from pSPN, resulting in the release of CRISPR/Cas9 plasmids and subsequently initiating gene editing. This system affords 15- and 1.8-fold enhancement in repaired gene expression relative to the nonirradiated controls in living cells and mice, resp. As this approach does not require any specific modifications on biomol. components, pSPN represents the first generic nanotransducer for in vivo regulation of CRISPR/Cas9 gene editing.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, COA of Formula: C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Zhang, Maojie published the artcileSynergistic effect of fluorination on molecular energy level modulation in highly efficient photovoltaic polymers, Safety of 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, the publication is Advanced Materials (Weinheim, Germany) (2014), 26(7), 1118-1123, database is CAplus and MEDLINE.

Four newly designed donor-acceptor polymers were prepared and characterized. The results clearly, show that fluorination on the donor and the acceptor moieties has little influence on the optical properties, but a synergistic effect on lowering their mol. energy levels. Accordingly, the photovoltaic measurements show that the PSC (polymer solar cell) device based on the tri- P2fluorinated polymer, PBT-3F, shows an enhanced PCE of 8.6%, which is among the highest for PSCs with a single heterojuncνtion structure. Therefore, introducing fluorine atoms onto the appropriate positions of the donor units in D-A polymers will be a promising method to effectively tune their mol. energy levels of for applications in PSCs.

Advanced Materials (Weinheim, Germany) published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C12H14BNO2, Safety of 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Zhang, Maojie published the artcileA Large-Bandgap Conjugated Polymer for Versatile Photovoltaic Applications with High Performance, Quality Control of 1514905-24-8, the publication is Advanced Materials (Weinheim, Germany) (2015), 27(31), 4655-4660, database is CAplus and MEDLINE.

Herein, we synthesized a new copolymer PM6 based on 4,8-bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene(BDT-F) and 1,3-bis(thiophen-2-yl)-5,7-bis(2-ethylhexyl)benzo-[1,2-c:4,5-c’]dithiophene-4,8-dione (BDD). The optical, electrochem., and photovoltaic properties, the mol. packing pattern, and the morphol. of the blend lms were investigated. Compared with the nonfluorinated derivative PBDTBDD, PM6 exhibited a similar optical bandgap of 1.80 eV and a deeper HOMO level of -5.45 eV (-5.25 eV for PBDTBDD), which is beneficial for a high V_oc. BHJ PSCs based on PM6/PC71 BM with both conventional and inverted device structures were fabricated and showed promising photovoltaic performance: a high V_oc of 0.98 V and a PCE of 8% for the conventional devices and up to 9.2% for the inverted devices. Furthermore, the PM6/PC71BM based semitransparent device exhibited a PCE of 5.7%, which is among the highest values obtained for a semitransparent single-junction device. In addition, we found that the neat film of PM6 exhibited strong crystallinity and a dominant face on packing with respect to the electrodes, which is advantageous for charge transport. These results indicate that PM6 is a promising material for photovoltaic application.

Advanced Materials (Weinheim, Germany) published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C12H9N3O4, Quality Control of 1514905-24-8.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Raju, Telugu Bhim published the artcileHighly efficient and facile alkylation of 4H-cyclopenta-[2,1-b:3,4-b’]dithiophene in water, Safety of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is RSC Advances (2014), 4(71), 37738-37745, database is CAplus.

A new and highly convenient method to perform alkylation of 4H-cyclopenta-[2,1-b:3,4-b’]dithiophene (CPDT) in aqueous conditions is reported. This method was also extended to successfully perform alkylation of 2,6-dibromo-4H-cyclopenta-[2,1-b:3,4-b’]dithiophene for the first time. This facile method has several advantages such as the exclusive use of water instead of high boiling toxic solvents, simple separation of the defect free dialkylated CPDT product I (Y = H, Br; R = hexyl, octyl, 5-bromopentyl, etc.) and the use of mild reaction conditions. Despite using mild reagents and reaction conditions, very high yields of up to 98% pure dialkylated CPDT products I are obtained much more readily by this method in less time than literature procedures. The desired dialkylated product with the alkyl halides used here.

RSC Advances published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Safety of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Chapman, Norman Bellamy published the artcileProton magnetic resonance spectra of some benzo[b]thiophene derivatives, HPLC of Formula: 17515-00-3, the publication is Journal of the Chemical Society [Section] C: Organic (1968), 764-9, database is CAplus.

Attempts are made to correlate the chem. shifts in the 100 Mc./sec. 1H N.M.R. spectra of 42 benzo[b]thiophene derivatives with the substituents present in the mol., and the relations are rationalized where possible. Coupling constants are also recorded, and their dependence on bond order and on other factors is discussed. The changes in the chem. shifts and coupling constants when the benzo[b]thiophenes are oxidized to the 1,1-dioxides are recorded and discussed. 43 references.

Journal of the Chemical Society [Section] C: Organic published new progress about 17515-00-3. 17515-00-3 belongs to benzothiophene, auxiliary class 5.6_Aromatics,Benzothiophens, name is 5-(tert-Butyl)benzo[b]thiophene, and the molecular formula is C12H14S, HPLC of Formula: 17515-00-3.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Lyu, Yan published the artcileDendronized Semiconducting Polymer as Photothermal Nanocarrier for Remote Activation of Gene Expression, Recommanded Product: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is Angewandte Chemie, International Edition (2017), 56(31), 9155-9159, database is CAplus and MEDLINE.

Regulation of transgene systems is needed to develop innovative medicines. However, noninvasive remote control of gene expression has been rarely developed and remains challenging. We herein synthesize a near-IR (NIR) absorbing dendronized semiconducting polymer (DSP) and utilize it as a photothermal nanocarrier not only to efficiently deliver genes but also to spatiotemporally control gene expression in conjunction with heat-inducible promoter. DSP has a high photothermal conversion efficiency (44.2 %) at 808 nm, permitting fast transduction of NIR light into thermal signals for intracellular activation of transcription. Such a DSP-mediated remote activation can rapidly and safely result in 25- and 4.5-fold increases in the expression levels of proteins in living cells and mice, resp. This study thus provides a promising approach to optically regulate transgene systems for on-demand therapeutic transgene dosing.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Recommanded Product: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Li, Jingchao published the artcileOrganic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy, Formula: C21H26Br4S2, the publication is Angewandte Chemie, International Edition (2019), 58(36), 12680-12687, database is CAplus and MEDLINE.

In this study, an organic semiconducting pro-nanostimulant (OSPS) with a near-IR (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises a semiconducting polymer nanoparticle (SPN) core and an immunostimulant conjugated through a singlet oxygen (¹O₂) cleavable linkers. Upon NIR laser irradiation, OSPS generates both heat and ¹O₂ to exert combinational phototherapy not only to ablate tumors but also to produce tumor-associated antigens. More importantly, NIR irradiation triggers the cleavage of ¹O₂-cleavable linkers, triggering the remote release of the immunostimulants from OSPS to modulate the immunosuppressive tumor microenvironment. Thus, the released tumor-associated antigens in conjunction with activated immunostimulants induce a synergistic antitumor immune response after OSPS-mediated phototherapy, resulting in the inhibited growth of both primary/distant tumors and lung metastasis in a mouse xenograft model, which is not observed for sole phototherapy.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Formula: C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Jiang, Yuyan published the artcileAmphiphilic semiconducting polymer as multifunctional nanocarrier for fluorescence/photoacoustic imaging guided chemo-photothermal therapy, Name: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is Biomaterials (2017), 168-177, database is CAplus and MEDLINE.

Chemo-photothermal nanotheranostics has the advantage of synergistic therapeutic effect, providing opportunities for optimized cancer therapy. However, current chemo-photothermal nanotheranostic systems generally comprise more than three components, encountering the potential issues of unstable nanostructures and unexpected conflicts in optical and biophys. properties among different components. We herein synthesize an amphiphilic semiconducting polymer (PEG-PCB) and utilize it as a multifunctional nanocarrier to simplify chemo-photothermal nanotheranostics. PEG-PCB has a semiconducting backbone that not only serves as the diagnostic component for near-IR (NIR) fluorescence and photoacoustic (PA) imaging, but also acts as the therapeutic agent for photothermal therapy. In addition, the hydrophobic backbone of PEG-PCB provides strong hydrophobic and π-π interactions with the aromatic anticancer drug such as doxorubicin for drug encapsulation and delivery. Such a trifunctionality of PEG-PCB eventually results in a greatly simplified nanotheranostic system with only two components but multimodal imaging and therapeutic capacities, permitting effective NIR fluorescence/PA imaging guided chemo-photothermal therapy of cancer in living mice. Our study thus provides a mol. engineering approach to integrate essential properties into one polymer for multimodal nanotheranostics.

Biomaterials published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Name: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Chapman, Norman Bellamy published the artcilePharmacologically active benzo[b]thiophene derivatives. IV. 5- and 6-Alkyl derivatives with an N-alkyl-N-(2-chloroethyl)aminomethyl group in the 3-position, Product Details of C12H14S, the publication is Journal of the Chemical Society [Section] C: Organic (1968), 514-17, database is CAplus and MEDLINE.

3-Chloromethylbenzo[b]thiophene reacted with N-ethyl-, N-isopropyl-, N-butyl-, N-tert-butyl, or N-benzylethanolamine to give the corresponding N-alkyl – N – (2 – hydroxyethyl) – 3 – aminomethylbenzo[b]thiophene derivatives With SOCl2 in dry CHCl3 these amino alcs. gave the corresponding N-alkyl-N-(2-chloroethyl)-3-aminomethylbenzo[b]thiophene hydrochlorides. A similar range of compounds was obtained from 5- or 6-methylbenzo[b]thiophene but only the N-Et derivative was prepared from 5-ethyl-, 5-isopropyl-, or 5-tert – butylbenzo[b]thiophene. N,N – Bis(2 – hydroxyethyl) – 3-aminomethylbenzo[b]thiophene and its 5-Et derivative were also prepared and converted into the corresponding nitrogen mustards. These compounds were evaluated pharmacol., with special emphasis on their anti-5HT and antitumor activity.

Journal of the Chemical Society [Section] C: Organic published new progress about 17515-00-3. 17515-00-3 belongs to benzothiophene, auxiliary class 5.6_Aromatics,Benzothiophens, name is 5-(tert-Butyl)benzo[b]thiophene, and the molecular formula is C12H14S, Product Details of C12H14S.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem