He, Shasha published the artcileCharge-Reversal Polymer Nano-modulators for Photodynamic Immunotherapy of Cancer, Related Products of benzothiophene, the publication is Angewandte Chemie, International Edition (2021), 60(35), 19355-19363, database is CAplus and MEDLINE.
Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for cancer immunotherapy. We report a charge-reversal polymer nano-modulator (SPDMCN) activated by tumor microenvironment (TME) for photodynamic immunotherapy of cancer. SPDMCN is constructed by conjugating an immunomodulator (demethylcantharidin, DMC) to the side chains of a photodynamic polymer via an acid-liable linker. The neg. charge of SPDMCN ensures its high stability in blood circulation and ideal tumor accumulation; exposure to acidic TME reverses its surface charge to pos., enhancing tumor penetration and locally releasing DMC. Upon near-IR photoirradiation, SPDMCN generates singlet oxygen to ablate tumors and promote maturation of dendritic cells. Released DMC inhibits protein phosphatase 2 (PP2A) activity and decreases Tregs differentiation. Such combinational action induces a sharp increase in CTL/Treg ratio in TME and effectively inhibits both primary and distant tumors in living mice.
Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Related Products of benzothiophene.
Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem