Cherney, Emily C. published the artcileDiscovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization, Category: benzothiophene, the publication is Journal of Medicinal Chemistry (2022), 65(4), 3518-3538, database is CAplus and MEDLINE.
The identification of agonists of the stimulator of interferon genes (STING) pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncol. therapy. Initial efforts to identify STING agonists focused on the modification of 2′,3′-cGAMP (1) (an endogenous STING activator ligand) and other closely related cyclic dinucleotides (CDNs). While these efforts have successfully identified novel CDNs that have progressed into the clinic, their utility is currently limited to patients with solid tumors that STING agonists can be delivered to intratumorally. Herein, we report the discovery of a unique class of non-nucleotide small-mol. STING agonists that demonstrate antitumor activity when dosed intratumorally in a syngeneic mouse model.
Journal of Medicinal Chemistry published new progress about 129425-81-6. 129425-81-6 belongs to benzothiophene, auxiliary class Inhibitor, name is 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid, and the molecular formula is C14H14O5S, Category: benzothiophene.
Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem