Day: November 21, 2022

Aldrich, Thomas J. published the artcileStable Postfullerene Solar Cells via Direct C-H Arylation Polymerization. Morphology-Performance Relationships, COA of Formula: C34H40F2S4, the publication is Chemistry of Materials (2019), 31(11), 4313-4321, database is CAplus.

The scope of the environmentally benign direct C-H arylation polymerization (DARP) process is validated and significantly extended in the synthesis of a high-performance benzodithiophene-based copolymer series, PBDT(Ar)-FTTE, with previously untested and systematically varied heteroaryl (Ar) substituents. Bulk-heterojunction (BHJ) polymer solar cells (PSCs) containing the high-performance nonfullerene acceptor (NFA) ITIC-Th and DARP-derived donors are fabricated and evaluated, yielding PCEs as high as 8%. The relationships between Ar-sensitive copolymer structure, BHJ morphol., and PSC performance are elucidated through in-depth characterization of structural order, phase separation, and charge transport using SCLC, AFM, GIWAXS, R-SoXS, and NEXAFS measurements, which conclusively demonstrate the important effects of Ar-tunable, dimensionally smaller, and well-blended copolymer domains for maximum PSC performance. Smaller BHJ copolymer domains having greater ITIC-Th miscibility definitively correlate with enhanced JSC, FF, and PCE metrics. Surprisingly regarding cell performance durability, while unencapsulated PBDTT-FTTE:ITIC-Th PSCs deliver the highest initial PCE, the unencapsulated PBDTTF-FTTE:ITIC-Th devices exhibit the optimum combination of high initial photovoltaic metrics and stability, retaining nearly 90% of the initial PCE after 51 days in ambient conditions and 83% of initial PCE after 180 min under simulated solar illumination. Importantly, for this PBDT(Ar)-FTTE:ITIC-Th series, PSC photovoltaic stability correlates with the presence of large pure BHJ domains, and moreover rivals or exceeds the stability of the analogous fullerene-based PSCs. Together, these results argue that solar cells prepared with the environmentally benign DARP process and NFAs are promising for both greener and more stable solar energy generation.

Chemistry of Materials published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C34H40F2S4, COA of Formula: C34H40F2S4.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Shang, Ziya published the artcileNon-equivalent D-A copolymerization strategy towards highly efficient polymer donor for polymer solar cells, HPLC of Formula: 1514905-24-8, the publication is Science China: Chemistry (2021), 64(6), 1031-1038, database is CAplus.

D-A copolymerization is a broadly utilized mol. design strategy to construct high efficiency photovoltaic materials for polymer solar cells (PSCs), and all the D-A copolymer donors reported till now are the alternate D-A copolymers with equal D-and A-units. Here, we first propose a non-equivalent D-A copolymerization strategy with unequal D- and A-units, and develop three novel non-equivalent D-A copolymer donors (PM6-D1, PM6-D2 and PM6-D3 with D/A unit ratio of 1.1:0.9, 1.2:0.8 and 1.3:0.7, resp.) by inserting more D units into the alternate D-A copolymer PM6 backbone to finely tune the physicochem. and photovoltaic properties of the polymers. The three non-equivalent D-A copolymers show the down-shifted HOMO (HOMO) energy levels, higher hole mobility, higher degree of mol. self-assembly and higher mol. crystallinity with the increase of D-unit ratio in comparison with the alternate D-A copolymer PM6. As a result, all the three non-equivalent D-A copolymer-based PSCs with Y6 as acceptor achieve improved power conversion efficiency (PCE) with higher Voc, larger Jsc and higher FF simultaneously. Particularly, the PM6-D1:Y6 based PSC achieved a high PCE of 17.71%, which is significantly higher than that (15.82%) of the PM6:Y6 based PSC and is one of the highest performances in the binary PSCs.

Science China: Chemistry published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C6H4ClNO2, HPLC of Formula: 1514905-24-8.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Yuan, Xiyue published the artcilePolythiophenes for organic solar cells with efficiency surpassing 17%, HPLC of Formula: 1514905-24-8, the publication is Joule (2022), 6(3), 647-661, database is CAplus.

Polythiophenes (PTs) are promising electron donors for organic solar cells (OSCs) due to their low production cost. However, the device performance of PTs in OSCs is rather poor due to unmatched energy levels and unfavorable active layer morphol. Herein, we report a set of new PTs (P5TCN-Fx) with cyano-group substitutions and varied fluorination degrees to achieve high-efficiency OSCs. The incorporation of the cyano-group endows the new PTs with deep-lying energy levels, and backbone fluorination leads to strong interchain interaction, improved polymer crystallinity, and appropriate thermodn. miscibility with the prevailing acceptor Y6 for the new PTs. As a result, multiple PTs have offered over 16% efficiency in binary OSCs. Moreover, a prominent PCE of 17.2% has been obtained by P5TCN-F25 via ternary blend design, which is the new efficiency record and represents a big breakthrough for PT-based OSCs. This work opens a promising avenue to achieve high-performance OSCs from low-cost materials.

Joule published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C14H26O2, HPLC of Formula: 1514905-24-8.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Yuan, Xiyue published the artcileAchieving 16% Efficiency for Polythiophene Organic Solar Cells with a Cyano-Substituted Polythiophene, Application In Synthesis of 1514905-24-8, the publication is Advanced Functional Materials (2022), 32(24), 2201142, database is CAplus.

Polythiophenes (PTs) are promising electron donors in organic solar cells (OSCs) due to their simple structures and excellent synthetic scalability. However, the device performance of PT-based OSCs is rather poor due mainly to large photon energy losses and an unfavorable active layer morphol. Herein, the authors report a new PT, which is abbreviated as P5TCN-2F and features cyano-group substituents for high-efficiency OSCs. The cyano-group endows P5TCN-2F with a deep-lying HOMO energy level, which thereby contributed to high open-circuit voltage in OSCs as a result of reduced non-radiative recombination energy loss. Moreover, the cyano-group leads to strong interchain interaction, improved polymer crystallinity, and appropriate miscibility with the prevailing non-fullerene acceptors. Consequently, P5TCN-2F offers over 15% power conversion efficiency when blended with various Y-series non-fullerene acceptors (Y6, Y6-BO, eC9, and L8-BO). Particularly, a champion efficiency of 16.1% is obtained by the P5TCN-2F:Y6 blend, which is largely higher than that of any previous PT-based OSCs. Moreover, the average figure of merit of the active layer based on P5TCN-2F is much superior to that of benzodithiophene-based polymers. These results suggest the renaissance of PT-based OSCs and have opened an avenue to access high-performance materials for the large-scale production of OSC modules.

Advanced Functional Materials published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C20H18BrN3, Application In Synthesis of 1514905-24-8.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Yu, Ningyue published the artcileRadioactive organic semiconducting polymer nanoparticles for multimodal cancer theranostics, Synthetic Route of 1426829-76-6, the publication is Journal of Colloid and Interface Science (2022), 219-228, database is CAplus and MEDLINE.

Theranostics with integrations of both imaging and therapeutic elements can enable early diagnosis and effective treatment of cancer. Herein, we report the development of radioactive semiconducting polymer nanoparticles (rSPNs) for multimodal cancer theranostics. Such rSPNs constructed through labeling poly(ethylene glycol) (PEG) grafted SPNs with iodine-131 (¹³¹I) exhibit ideal photothermal property, excellent singlet oxygen (¹O₂) generating ability and good radiolabeling stability. Owing to their small particle dimension and PEG surface corona, rSPNs show an effective accumulation into s.c. tumors of living mice after systemic administration. The good fluorescence property and stable radiolabeling of rSPNs enable contrast signals for near-IR (NIR) fluorescence and single photon emission computed tomog. (SPECT) dual-model imaging of tumors. Moreover, rSPNs provide combinational action of photothermal therapy (PTT), photodynamic therapy (PDT) and radiotherapy under NIR laser irradiation, resulting in much higher therapeutic efficacy in inhibiting tumor growth and metastasis relative to SPNs-mediated treatment. This study thus offers a multifunctional organic nanosystem for multimodal cancer theranostics.

Journal of Colloid and Interface Science published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C18H10, Synthetic Route of 1426829-76-6.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Henson, Zachary B. published the artcileSynthesis and Properties of Two Cationic Narrow Band Gap Conjugated Polyelectrolytes, COA of Formula: C21H26Br4S2, the publication is Journal of the American Chemical Society (2013), 135(11), 4163-4166, database is CAplus and MEDLINE.

We report the design, synthesis, and optical and electronic properties of two novel narrow band gap conjugated polyelectrolytes (NBGCPEs) based on a poly[2,6-(4,4-bis-alkyl-4H-cyclopenta[2,1-b;3,4-b’]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] donor/acceptor backbone. Comparison with the properties of the neutral precursor material shows that the ionic component in these cationic NBGCPEs leads to a red-shift in the absorption spectra and to a modification of the polymer electronic energy levels. Both the HOMO and the LUMO are lowered in energy, with the net effect being dependent on the choice of counterion, i.e. bromide vs. tetrakis(1-imidazolyl)borate. Moreover, we unexpectedly find n-type transport in thin-film transistors, as opposed to the widely studied p-type transport in neutral systems with isoelectronic backbones. From these observations we conclude that introduction of ionic functionalities adjacent to semiconducting polymers that exhibit charge-transfer excitations offers unique opportunities for materials design.

Journal of the American Chemical Society published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, COA of Formula: C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Cherney, Emily C. published the artcileDiscovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization, Category: benzothiophene, the publication is Journal of Medicinal Chemistry (2022), 65(4), 3518-3538, database is CAplus and MEDLINE.

The identification of agonists of the stimulator of interferon genes (STING) pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncol. therapy. Initial efforts to identify STING agonists focused on the modification of 2′,3′-cGAMP (1) (an endogenous STING activator ligand) and other closely related cyclic dinucleotides (CDNs). While these efforts have successfully identified novel CDNs that have progressed into the clinic, their utility is currently limited to patients with solid tumors that STING agonists can be delivered to intratumorally. Herein, we report the discovery of a unique class of non-nucleotide small-mol. STING agonists that demonstrate antitumor activity when dosed intratumorally in a syngeneic mouse model.

Journal of Medicinal Chemistry published new progress about 129425-81-6. 129425-81-6 belongs to benzothiophene, auxiliary class Inhibitor, name is 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid, and the molecular formula is C14H14O5S, Category: benzothiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Akay, Senol published the artcileSynthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar sensing, Recommanded Product: Benzo[b]thiophen-7-ylboronic acid, the publication is Chemical Biology & Drug Design (2007), 70(4), 279-289, database is CAplus and MEDLINE.

Cell surface glycoproteins have been known to play very important roles in various physiol. and pathol. processes. Small mol. compounds capable of carbohydrate recognition can be very useful for the development of sensing, diagnostic, and therapeutic agents. Along this line, the authors are interested in developing water-soluble fluorescent boronic acid compounds for carbohydrate recognition. As such, a series of benzo[b]thiophene boronic acid derivatives have been synthesized and their fluorescent properties analyzed at physiol. pH. Benzo[b]thiophene derivatives were a new type of fluorescent reporter compounds capable of dual fluorescent emission under physiol. pH conditions. Many of the synthesized Compounds showed unusual emission wavelength shifts upon binding of sugars. These boronic acids will be useful tools for building glycoprotein biosensors for biol. applications.

Chemical Biology & Drug Design published new progress about 628692-17-1. 628692-17-1 belongs to benzothiophene, auxiliary class Boronic acid and ester,Benzothiophene,Benzothiophene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is Benzo[b]thiophen-7-ylboronic acid, and the molecular formula is C8H7BO2S, Recommanded Product: Benzo[b]thiophen-7-ylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Akay, Senol published the artcileSynthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar sensing, Recommanded Product: (1-Benzothiophen-4-yl)boronic acid, the publication is Chemical Biology & Drug Design (2007), 70(4), 279-289, database is CAplus and MEDLINE.

Cell surface glycoproteins have been known to play very important roles in various physiol. and pathol. processes. Small mol. compounds capable of carbohydrate recognition can be very useful for the development of sensing, diagnostic, and therapeutic agents. Along this line, the authors are interested in developing water-soluble fluorescent boronic acid compounds for carbohydrate recognition. As such, a series of benzo[b]thiophene boronic acid derivatives have been synthesized and their fluorescent properties analyzed at physiol. pH. Benzo[b]thiophene derivatives were a new type of fluorescent reporter compounds capable of dual fluorescent emission under physiol. pH conditions. Many of the synthesized Compounds showed unusual emission wavelength shifts upon binding of sugars. These boronic acids will be useful tools for building glycoprotein biosensors for biol. applications.

Chemical Biology & Drug Design published new progress about 177735-30-7. 177735-30-7 belongs to benzothiophene, auxiliary class Boronic acid and ester,Benzothiophene,Boronic Acids,Boronic acid and ester, name is (1-Benzothiophen-4-yl)boronic acid, and the molecular formula is C8H7BO2S, Recommanded Product: (1-Benzothiophen-4-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Li, Jingchao published the artcileSemiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy, Product Details of C21H26Br4S2, the publication is Angewandte Chemie, International Edition (2018), 57(15), 3995-3998, database is CAplus and MEDLINE.

Regulation of enzyme activity is fundamentally challenging but practically meaningful for biol. and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near-IR (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5-fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Product Details of C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem