Shinosaki, Toshihiro published the artcileStop-flow studies on tubular transport of uric acid in rats, Synthetic Route of 40180-04-9, the main research area is kidney tubule urate transport uricosuric.
A stop-flow technique using pyrazinoic acid (PZO)-treated and -untreated rats was devised to evaluate drug effects on bi-directional transport of uric acid in the tubules. Constant venous infusion of test drugs to PZO-untreated rats was used to estimate their inhibitory effects on urate secretion, while their inhibitory effects on urate reabsorption was studied by i.v. administration as a bolus to PZO-treated rats. Probenecid, tienilic acid and R(+)-enantiomer of S-8666, which is the uricosuric component of a new uricosuric diuretic, decreased the (Tua/Pua)/(Tin-Pin) value in the distal and proximal tubules by inhibiting urate secretion in PZO-untreated rats. On the other hand, all of these drugs increased the (Tua/Pua)/(Tin/Pin) value in the tubules in PZO-treated rats, which suggested that they also inhibited the reabsorptive flux of urate. This stop-flow technique in rat kidney showed the possibilities of bi-directional inhibition by these drugs of urate transport in the tubules.
Advances in Experimental Medicine and Biology published new progress about Gout. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Synthetic Route of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem