Oker-Blom, Christian published the artcileToxicological studies on tienilic acid in rats, Safety of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is tienilic acid toxicity; sex tienilic acid toxicity.
The subacute oral toxicity of tienilic acid (I) [40180-04-9] in male and female rats was studied. Animals were given 0, 30, 120, and 480 mg I/kg as a 3% gum arabic suspension for 28 days. At 30 mg I/kg, blood pressure and serum uric acid [69-93-2] decreased. At the 2 higher dose levels, a slight decrease in Hb and an increase in serum glutamic-pyruvic transaminase [9000-86-6] activity was noticed, and there was a significant increase in the liver weight and serum Mg concentration of male rats, while the liver weight of female rats increased only slightly. One microscopic examination, unicellular necrosis of small groups of liver cells was noted, together with focal round-cell infiltration and some stasis of the 2 higher dose levels in some animals. I had no noticeable effects on other organs or parameters.
Toxicology Letters published new progress about Blood. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Safety of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem