Huang, Tao published the artcilePrediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles, Quality Control of 40180-04-9, the main research area is xenobiotic drug discovery toxicity prognosis.
More and more people are concerned by the risk of unexpected side effects observed in the later steps of the development of new drugs, either in late clin. development or after marketing approval. To reduce the risk of the side effects, it is important to look out for the possible xenobiotic responses at an early stage. The authors attempt such an effort through a prediction by assuming that similarities in microarray profiles indicate shared mechanisms of action and/or toxicol. responses among the chems. being compared. A large time course microarray database derived from livers of compound-treated rats with thirty-four distinct pharmacol. and toxicol. responses were studied. The mRMR (Min.-Redundancy-Maximum-Relevance) method and IFS (Incremental Feature Selection) were used to select a compact feature set (141 features) for the reduction of feature dimension and improvement of prediction performance. With these 141 features, the Leave-one-out cross-validation prediction accuracy of first order response using NNA (Nearest Neighbor Algorithm) was 63.9%. The authors’ method can be used for pharmacol. and xenobiotic responses prediction of new compounds and accelerate drug development.
PLoS One published new progress about Basophil. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Quality Control of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem