Guariglia, A. published the artcileMetabolic effects of a natriuretic-uricosuric drug, Ticrynafen, in man, Related Products of benzothiophene, the main research area is Ticrynafen urate sodium potassium metabolism; acid base equilibrium Ticrynafen.
Ticrynafen (I) [40180-04-9] (500 mg) has a maximal diuretic and natriuretic effect in human subjects during the 1st 2 and 3 days after treatment, resp. A significant natriuretic effect was also observed in subjects with reduced glomerular filtration rates. During a period of maximum water and Na+ excretion, the urinary K+ losses were not significant. The urinary K+ losses were only late, after the maximal natriuretic effect. The observed changes in acid-base balance indicated that the development of metabolic acidosis was related to K+ depletion and that it might be prevented by administration of K+-sparing diuretics. Increases in blood and urine uric acid [69-93-2] were observed in all subjects treated with I, including patients with reduced glomerular filteration rates.
International Congress Series published new progress about Ticrynafen urate sodium potassium metabolism; acid base equilibrium Ticrynafen. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Related Products of benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem