Freis, Edward published the artcileComparative effects of ticrynafen and hydrochlorothiazide in the treatment of hypertension, Application of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is ticrynafen hydrochlorothiazide hypertension.
Two dose levels of ticrynafen (I) [40180-04-9], a new uricosuric diuretic, and of hydrochlorothiazide [58-93-5] were randomly assigned double-blind to 240 men with initial diastolic blood pressures in the range of 95 to 114 mm Hg. A dose of 500 mg of I once daily exerted an antihypertensive effect comparable to that of 50 or 100 mg of hydrochlorothiazide. Whereas serum uric acid [69-93-2] levels rose in patients treated with hydrochlorothiazide, they fell markedly in those receiving I. Otherwise, both diuretics produced similar chem. changes in serum. Patients tolerated I as well as they did hydrochlorothiazide over a period of 6 mo of observation, and there was no evidence of serious toxicity or loss of therapeutic effect with I. This antihypertensive agent, in appropriate doses, appears to be as effective and well tolerated as hydrochlorothiazide, and in addition I prevents hyperuricemia.
New England Journal of Medicine published new progress about ticrynafen hydrochlorothiazide hypertension. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Application of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem