Dayan, J. published the artcileStudy of the mutagenic activity of 6 hepatotoxic pharmaceutical drugs in the Salmonella typhimurium microsome test, and the HGPRT and sodium-potassium ATPase system in cultured mammalian cells, SDS of cas: 40180-04-9, the main research area is hepatotoxic drug mutagenicity.
Several pharmaceutical drugs show strong hepatotoxicity during therapeutic use: aminophenazone [58-15-1], clofibrate [637-07-0], nifuroxazide [965-52-6], oxamniquine [21738-42-1], perhexiline maleate [6724-53-4], and tienilic acid [40180-04-9]. Their mutagenicity was assessed in the Ames test on 6 strains of S. typhimurium, and in V79 Chinese hamster lung cells with a rat-hepatocyte-mediated metabolic activation system and the hypoxanthine-guanine phosphoribosyl transferase test and the Na+/K+ ATPase assay. Nifuroxazide was pos. in the Ames test in 2 Salmonella strains (TA100 and TA100 Frl). In the hepatocyte-mediated mammalian V79 cell system, nifuroxazide, clofibrate, and aminophenazone were neg. Oxamniquine and tienilic acid were pos. with and without metabolic activation in tests for ouabain and 6-thioguanine resistance. Perhexiline maleate was neg. for the direct induction of 6-thioguanine resistance without metabolic activation, and pos. after metabolization mediated by primary rat hepatocytes. These results suggest the need for some caution in the use of some pharmaceutical drugs because of hepatotoxicity and because 3 out of 6 drugs were shown to be slightly mutagenic in mammalian cells.
Mutation Research, Genetic Toxicology Testing published new progress about Liver. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, SDS of cas: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem