Dan, Takashi published the artcileA selective uricosuric action of AA-193 in rats: comparison with its effect on PAH secretion in vivo and in vitro, Quality Control of 40180-04-9, the main research area is AA193 kidney urate diuresis PAH.
The uricosuric action of AA-193 was compared with the effect on PAH secretion in rats. I.v. administration of AA-193 elevated the fractional excretion of urate (FEu4ate) in a dose-dependent manner at doses 0.1-10 mg/kg. Only at the highest dose caused a momentary decrease in FEPAH. Tienilic acid and probenecid reduced FEPAH at uricosuric EDs. To compare the inhibitory effects of uricosurics on urate reabsorption and PAH secretion more directly, the effects of uricosurics on the OH- gradient-dependent urate uptake were studied in brush-border membrane vesicles and the net PAH accumulation in cortical renal slices. The relation between the affinity of uricosuric drug for urate and PAH transporters corresponded well with the difference between the effects on FEurate and FEPAH. The relative affinity of AA-193 for the urate uptake was 83-fold greater than that for the PAH accumulation. In contrast with other uricosurics, AA-193 has a much higher affinity for urate reabsorption system than for the common pathway of weak organic acids in rats.
Naunyn-Schmiedeberg’s Archives of Pharmacology published new progress about Diuresis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Quality Control of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem