Ahokas, Jorma T. published the artcileInhibition of purified rat liver glutathione S-transferase isozymes by diuretic drugs, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is glutathione transferase inhibition diuretic.
Seven soluble rat liver glutathione S-transferase [50812-37-8] isozymes were isolated, and the inhibition of these isozymes by selected diuretics was investigated, using 1-chloro-2,4-dinitrobenzene as substrate. All the isozymes were inhibited to some extent, but there was significant isozyme-dependent selectivity of inhibition. The greatest inhibitory effect (80%) was found when phenoxyacetic acid-type diuretics and indacrynic acid [56049-88-8] were incubated with glutathione S-transferase isozymes 3-3, 3-4, and 4-4. The sulfamoylbenzoic acid diuretics furosemide [54-31-9] and bumetanide [28395-03-1] had a lesser effect on the isozymes studied. As glutathione S-transferases are thought to play an important protective role in the various tissues of animals and man, by catalyzing the glutathione conjugation of electrophilic drugs and drug metabolites, their inhibition may be toxicol. important.
Biochemical Pharmacology published new progress about Diuretics. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem