Ahokas, J. T. published the artcileThe effect of tienilic acid on paracetamol toxicity, Related Products of benzothiophene, the main research area is tienilate paracetamol toxicity glutathione transferase.
Tienilic acid (I) [40180-04-9] inhibited the activity of mouse liver cytosolic glutathione-S-transferase (GSH-t) [50812-37-8] in vitro, with inhibition ranging 23-48%. In mice, the administration of paracetamol (II) [103-90-2] (302 mg/kg, i.p.), a drug normally detoxified through conjugation by the GSH-t system, along with I (40 mg/kg, i.p.) did not result in an increase of II toxicity. Thus, the interaction between II and a strong GSH-t inhibitor, I, does not lead to enhanced II toxicity. Results are discussed with respect to II detoxification via GSH-t.
IRCS Medical Science published new progress about Cytosol. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Related Products of benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem