Acosta, Daniel published the artcileLack of cytotoxicity of ticrynafen in primary cultures of rat liver cells, HPLC of Formula: 40180-04-9, the main research area is tricrynafen cytotoxicity liver.
Primary cultures of hepatocytes obtained from neonatal Sprague-Dawley rats were grown in arginine-deficient, ornithine-supplemented medium to inhibit fibroblastic overgrowth and to selectively isolate relatively pure cultures of parenchymal hepatocytes. This system of primary hepatocytes was used to study the potential cytotoxicity of ticrynafen (I) [40180-04-9] by measuring cytoplasmic enzyme leakage, cell viability, and total protein per culture dish. Hepatic cultures were treated with the drug in concentrations ranging from 10-3 M to 10-6 M and for durations from 2 to 8 h. The results of the study indicate that ticrynafen was minimally toxic to the hepatocytes.
Toxicology Letters published new progress about Liver. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem