Vukusic, Ivo published the artcileQuantitative thin-layer chromatographic determination of ticrynafen in canine plasma, SDS of cas: 40180-04-9, the main research area is ticrynafen determination blood; chromatog thin layer ticrynafen blood.
After extraction from plasma with CHCl3, ticrynafen (I) [40180-04-9] was chromatographed on silica-gel K6F thin-layer-chromatog. plates with EtOAc-HOAc (95:5) as the developing solvent. I was determined with a dual-wavelength thin-layer-chromatog. scanner, using 300 nm and 400 nm as the dual wavelengths. The lowest amount of I detectable was 0.1 μg/spot (33 μg/mL), and linear responses were obtained up to 7.5 μg/spot. The relative standard deviations for plasma samples of 3.3-25.0 μg/mL ranged 3.6-13.6%. Recoveries were 75.3% at 3.3 μg/mL and 82.3% at 16.7 μg/mL. The accuracy of the assay was good, the difference between the observed and theor. concentrations for plasma samples of 1.0-7.5 μg/spot being 5.2%. The assay was used to determine I pharmacokinetics in the dog.
Journal of Chromatography, Biomedical Applications published new progress about Blood analysis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, SDS of cas: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem