Randolph, W. C.’s team published research in Journal of Pharmaceutical Sciences in 1979-11-30 | CAS: 40180-04-9

Journal of Pharmaceutical Sciences published new progress about Blood analysis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Synthetic Route of 40180-04-9.

Randolph, W. C. published the artcileHigh-pressure liquid chromatographic analysis of ticrynafen and one of its metabolites in urine and serum, Synthetic Route of 40180-04-9, the main research area is ticrynafen blood urine chromatog.

A method is described for the extraction of ticrynafen (I) [40180-04-9], a new hypotensive agent, and its reduced metabolite from serum and urine. Drug-related material is extracted from biol. fluids with ether under strongly acidic conditions and the back-extracted into an alk. aqueous phase, which is subjected to high-pressure liquid chromatog. anal. Separations are performed on a reversed-phase column with a mobile phase consisting of phosphate buffer-acetonitrile. The method measured serum concentrations of I and its reduced metabolite as low as 1.0 and 0.4 μg/mL, resp.

Journal of Pharmaceutical Sciences published new progress about Blood analysis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Synthetic Route of 40180-04-9.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem