Rana, Payal published the artcileDevelopment of a cell viability assay to assess drug metabolite structure-toxicity relationships, Category: benzothiophene, the main research area is drug metabolite toxicity assay cytochrome P 450 structure toxicity; Cytochrome P450; Drug-induced toxicity; Metabolic activation; Reactive metabolite; Structural alerts.
Many adverse drug reactions are caused by the cytochrome P 450 (CYP)-dependent activation of drugs into reactive metabolites. To reduce attrition due to metabolism-induced toxicity and to improve the safety of drug candidates, the authors developed a simple cell viability assay by combining a bioactivation system (human CYP3A4, CYP2D6 and CYP2C9) with Hep3B cells. The authors screened a series of drugs to explore structural motifs that may be responsible for CYP 450-dependent activation caused by reactive metabolite formation, which highlighted specific liabilities regarding certain phenols and anilines.
Bioorganic & Medicinal Chemistry Letters published new progress about Drug discovery. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem