Ramachandran, P. Veeraraghavan published the artcileTiCl4-Catalyzed Hydroboration of Ketones with Ammonia Borane, Formula: C6H6OS, the main research area is secondary alc preparation; ketone titanium chloride ammonia borane hydroboration reduction.
Investigation of a variety of Lewis acids for the hydroboration-hydrolysis (reduction) of ketones with amine-boranes has revealed that catalytic (10 mol %) titanium tetrachloride (TiCl4) in di-Et ether at room temperature immensely accelerates the reaction of ammonia borane. The product alcs. are produced in good to excellent yields within 30 min, even with ketones which typically requires 24 h or longer to reduce under uncatalyzed conditions. Several potentially reactive functionalities are tolerated, and substituted cycloalkanones are reduced diastereoselectively to the thermodn. product. A deuterium labeling study and 11B NMR anal. of the reaction have been performed to verify the proposed hydroboration mechanism.
Journal of Organic Chemistry published new progress about Hydroboration. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Formula: C6H6OS.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem