Pinkert, Tobias published the artcileUse of Strain-Release for the Diastereoselective Construction of Quaternary Carbon Centers, Safety of 3-Acetylthiophene, the main research area is methoxyiminoethyl arene bicyclobutanone ethyl glyoxylate rhodium catalyst three component; hydroxy methoxyiminoethyl arylvinyl succinate preparation diastereoselective.
The formation of quaternary carbon centers with excellent diastereoselectivity via a strain-release protocol were discussed. An organometallic species was generated by Cp*Rh(III)-catalyzed C-H activation, which was then coupled with strained bicyclobutanes (BCBs) and a prochiral carbon electrophile in a three-component reaction. A rare example of BCBs in transition metal catalysis and demonstrates their broad potential to access novel reaction pathways were illustrated. The method developed exhibited a ample functional group tolerance, and the obtained products were further transformed into valuable α-quaternary β-lactones. Preliminary mechanistic investigations suggested a two fold C-C bond cleavage sequence involving σ-bond insertion and an ensuing β-carbon elimination event.
Journal of the American Chemical Society published new progress about Alkenylation. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem