Odlind, Bo published the artcileTubular secretion and effects of tienilic acid in the hen, Product Details of C13H8Cl2O4S, the main research area is tienilic acid kidney tubule secretion.
The relationship between renal tubular secretion of the uricosuric diuretic tienilic acid (I) [40180-04-9] (10 or 30 μg/kg/min) and its saluretic effects was determined in hens using a modified Sperber technique. A true tubular excretion fraction (TTEF) of 29.9% (mean) for tienilic acid was reduced by novobiocin to 3.3%. This demonstrates active tubular secretion of the diuretic by an organic anion transport system in the hen kidney. Infusion of the diuretic into one leg vein caused a marked ipsilateral excess excretion of Cl-, Na+, and K+; these effects were reduced by novobiocin. Thus, in the hen a significant part of the saluretic effect of tienilic acid depends on the active secretion of the drug by tubular cells, as has previously been found for 3 loop diuretics i.e. ethacrynic acid, furosemide and piretanide. Apparently, the saluretic effect of tienilic acid is evoked mainly from the luminal side of the avian nephron. At an infusion rate of 20 μg/kg/min of tienilic acid, a marked saluresis occurred; there was, however, no effect on the urinary urate excretion.
European Journal of Pharmacology published new progress about Kidney tubule. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Product Details of C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem