Mondal, Arup published the artcileCatalyst-Controlled Regiodivergent C-H Alkynylation of Thiophenes, Synthetic Route of 1468-83-3, the main research area is thiophene regiodivergent alkynylation palladium catalyst; C−H activation; alkynylation; regiodivergent; regioselectivity; thiophenes.
Alkynes are highly attractive motifs in organic synthesis due to their presence in natural products and bioactive mols. as well as their versatility in a plethora of subsequent transformations. A common procedure to insert alkynes into (hetero)arenes, such as the thiophenes studied herein, consists of a halogenation followed by a Sonogashira cross-coupling. The regioselectivity of this approach depends entirely on the halogenation step. Similarly, direct alkynylations of thiophenes were described that follow the same regioselectivity patterns. Herein the authors report the development of a palladium catalyzed C-H activation/alkynylation of thiophenes. The method is applicable to a broad range of thiophene substrates. For 3-substituted substrates where controlling the regioselectivity between the C2 and C5 position is particularly challenging, two sets of reaction conditions enable a regiodivergent reaction, giving access to each regioisomer selectively. Both protocols use the thiophene as limiting reagent and show a broad scope, rendering the authors’ method suitable for late-stage modification.
Angewandte Chemie, International Edition published new progress about Alkynylation. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem