Mei, Haibo published the artcileIntramolecular Appel Reaction of Trifluoromethylated β-Keto Diazos Enabling Assembly of Trifluoromethylpyrazoles, Recommanded Product: 3-Acetylthiophene, the main research area is trifluoromethylpyrazole preparation; trifluoromethylated keto diazo compound intramol Appel.
A method for the generation of trifluoromethylated β-keto diazos, and their applications in intramol. Appel type reactions was reported for the synthesis of trifluoromethylpyrazoles I [R = Ph, 2-naphthyl, 2-furyl, etc.; R1 = CF3, CF2Cl, C2F5, etc.]. The key success of this reaction was diazo species as an N-nucleophile in Appel reactions. This reaction was conducted under mild conditions and had a broad substrate scope, affording trifluoromethylpyrazoles with up to 94% yields. This protocol represented a new type of Appel reaction and also a new reaction mode of fluoro diazoalkanes.
Organic Letters published new progress about Appel reaction. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem