Gomez-Lechon, Maria Jose published the artcileMechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project, COA of Formula: C13H8Cl2O4S, the main research area is development innovative hepatotoxicity LIINTOP project.
The 6th European Framework Program project LIINTOP was specifically raised to optimize and provide established protocols and exptl. in vitro models for testing intestinal and liver absorption, metabolism and toxicity of mols. of pharmacol. interest. It has been focused on some of the most promising existing liver and intestine in vitro models with the aim of further improving their performance and thus taking them to a pre-normative research stage. Regarding the specific area of the liver, a first basic approach was the optimization of in vitro hepatic models and the development and optimization of in vitro approaches for toxicity screening. New advanced technologies have been proposed and developed in order to determine cellular and mol. targets as endpoints of drug exposure. A key issue in the development and optimization of in vitro hepatotoxicity screening methods was the selection of structurally diverse suitable hepatotoxic reference model compounds to be tested. To this end, a number of solid selection criteria were defined (drugs preferably than chem. agents, well-documented hepatotoxicity in man and well-defined mechanism/s of hepatotoxicity, com. available no volatile compounds with unequivocal CAS number and chem. structure), the strategy followed, including all resources consulted, is described and the selected compounds are extensively illustrated.
Toxicology in Vitro published new progress about Drug screening. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, COA of Formula: C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem