Yonetani, Yukio published the artcileHyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats, Application In Synthesis of 40180-04-9, the main research area is antihypertensive uricosuric hyperuricemia pharmacol model.
The effects of antihypertensive and uricosuric drugs were studied on plasma and urinary levels of uric acid [69-93-2] in K oxonate [2207-75-2]-treated rats. Animals with a catheterized aorta were used to successively collect blood samples and this procedure simplified the evaluation of progressive changes of plasma uric acid, under successive loading with K oxonate. The plasma uric acid level of the oxonate-treated rats was increased even with a single administration of diuretic chlorothiazides, furosemide [54-31-9] and diazoxide [364-98-7], and also uricosuric drugs such as tienilic acid [40180-04-9] and probenecid [57-66-9]. A well-maintained plasma uric acid level was also produced by exogenously administered uric acid in rats given allopurinol and K oxonate. Diazoxide, tienilic acid, and probenecid increased the plasma uric acid, whereas diuretic chlorothiazides did not. Furosemide tended to decrease the plasma uric acid level at the early stage of administration in rats treated with allopurinol [315-30-0], oxonate, and uric acid, but increased these levels several hours later when the effect was studied by uric acid loading with rats treated with allopurinol and oxonate. These effects also appeared as changes in the urine-excreted uric acid. Thus, the oxonate-treated rats demonstrated an acutely induced hyperuricemia not only with certain antihypertensives, but also with uricosuric drugs. The utility of these procedures for evaluating the hyperuricemic and uricosuric effects of drugs is discussed.
Japanese Journal of Pharmacology published new progress about Antihypertensives. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Application In Synthesis of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem