Tighadouini, Said published the artcileSynthesis, Biochemical Characterization, and Theoretical Studies of Novel β-Keto-enol Pyridine and Furan Derivatives as Potent Antifungal Agents, Synthetic Route of 1468-83-3, the main research area is keto enol pyridine furan antifungal antibacterial mol docking dynamic.
In the present study, we report the design and synthesis of new derivatives of the β-keto-enol grafted on pyridine and furan moieties (L1-L11). Structures of compounds were fully confirmed by Fourier transform IR spectroscopy (FT-IR), 1H NMR, 13C NMR, electrospray ionization/liquid chromatog.-mass spectrometry (ESI/LC-MS), and elemental anal. The compounds were screened for antifungal and antibacterial activities (Escherichia coli, Bacillus subtilis, and Micrococcus luteus). In vitro evaluation showed significant fungicidal activity for I, II, and III against fungal strains (Fusarium oxysporum f.sp albedinis) compared to the reference standard Especially, the exceptional activity has been demonstrated for I with IC50 = 12.83μg/mL. This compound and the reference benomyl mol. also showed a correlation between exptl. antifungal activity and theor. predictions by Petra/Osiris/Molinspiration (POM) calculations and mol. coupling against the Fgb1 protein. The highest inhibition of bacterial growth for I is due to its strongest binding to the target protein. This report may stimulate the further synthesis of examples of this substance class for the development of new drugs.
ACS Omega published new progress about Antibacterial agents. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem