Snow, Ina B. published the artcileRenal sites of natriuretic and uricosuric activity of ticrynafen in the mongrel dog, Quality Control of 40180-04-9, the main research area is ticrynafen natriuresis uricosuria mechanism; resorption uric acid sodium ticrynafen.
Following establishment of steady state plasma concentrations of ticrynafen (I) [40180-04-9] in the mongrel dog, the i.v. injection of large doses of p-aminohippurate (PAH) or Na salicylate reduced or blocked the urinary excretion of I. In a similar manner, the i.v. administration of I reduced the urinary excretion of PAH in preloaded dogs. Since PAH and salicylate are actively secreted by a renal tubular organic anion transport system, these data provided evidence for an active tubular secretion of I. The natriuresis and uricosuria from the administration of I to the mongrel dog were reduced by PAH and salicylate at doses which effectively blocked the secretion of I. Apparently, in the dog, the natriuretic and uricosuric activity of I results from the presence of I in the tubular lumen.
Nephron published new progress about Resorption, animal. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Quality Control of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem