Preusch, Peter C. published the artcileMechanism of ticrynafen potentiation of coumarin anticoagulant action, HPLC of Formula: 40180-04-9, the main research area is coumarin anticoagulant ticrynafen interaction.
Ticrynafen (I) [40180-04-9] enhanced the degree of hypoprothrombinemia and altered plasma and hepatic vitamin K epoxide [25486-55-9] concentrations in warfarin (II) [81-81-2]-treated rats. Ticrynafen did not affect vitamin K-dependent carboxylase [81181-72-8] or vitamin K epoxide reductase [55963-40-1] activities in vitro. Cytosolic DT-diaphorase [9032-20-6] was very sensitive to ticrynafen inhibition in vitro, and inhibition of vitamin K [12001-79-5] reduction via this enzyme is a possible mechanism by which ticrynafen potentiates coumarin anticoagulant action. Inhibition of this enzyme may also contribute to the reported hepatotoxicity of ticrynafen.
Biochemical Pharmacology published new progress about Blood coagulation. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem