O’Reilly, Robert A. published the artcileTicrynafen-racemic warfarin interaction: hepatotoxic or stereoselective?, Product Details of C13H8Cl2O4S, the main research area is ticrynafen warfarin interaction stereoselective.
Normal subjects received large single doses of 1.5 mg/kg racemic warfarin (racemic I) [81-81-2] with and without daily oral doses of 250 mg ticrynafen (II) [40180-04-9] beginning 3 days before I and continuing for the duration of hypoprothrombinemia. II induced augmentations of both prothrombin time and plasma I concentration The interaction was evaluated further with separated I enantiomorphs. II induced augmentation of prothrombin times and I concentrations of S-I [5543-57-7], but had little effect on R-I [5543-58-8]. Thus, II probably augments the hypoprothrombinemia of racemic I by reducing metabolic clearance of S-I. The lack of effect of II on R-I suggests that the interaction is stereoselective rather than hepatotoxic.
Clinical Pharmacology & Therapeutics (St. Louis, MO, United States) published new progress about Drug interactions. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Product Details of C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem