Mitsumori, Susumu published the artcileSynthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D2 Receptor Antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives, Formula: C9H10O2S, the main research area is dimethylbicycloheptane prostaglandin derivative preparation; prostaglandin D2 receptor antagonist bicycloheptane skeleton preparation; antiallergenic dimethylbicycloheptane prostaglandin derivative preparation.
Novel prostaglandin D2 (PGD2) receptor antagonists having the bicyclo[2.2.1]heptane ring system as a prostaglandin skeleton are a potent new class of antiallergic agents and suppressed various allergic inflammatory responses such as those observed in conjunctivitis and asthma models. In the present study, PGD2 receptor antagonists having the 6,6-dimethylbicyclo[3.1.1]heptane ring system were synthesized. These derivatives have the amide moiety, in contrast to those with the bicyclo[2.2.1]heptane ring system, which have the sulfonamide group. The derivatives having the 6,6-dimethylbicyclo[3.1.1]heptane ring also exhibited strong activity in PGD2 receptor binding and cAMP formation assays. In in vivo assays such as allergic rhinitis, conjunctivitis, and asthma models, these series of derivatives showed excellent pharmacol. profiles. In particular, compound I also effectively suppressed eosinophil infiltration in allergic rhinitis and asthma models. This compound (I, S-5751) is now being developed as a promising alternative antiallergic drug candidate.
Journal of Medicinal Chemistry published new progress about Allergic rhinitis. 19156-54-8 belongs to class benzothiophene, name is 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, and the molecular formula is C9H10O2S, Formula: C9H10O2S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem