Maass, Alfred R. published the artcileRenal pharmacology of tienilic acid, Safety of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is tienilic acid pharmacol kidney; diuresis tienilic acid; natriuresis tienilic acid.
Tienilic acid (I) [40180-04-9] (10 mg/kg), administered i.v. to hydrated dogs, caused a moderate natriuresis, an increased osmolal clearance, and a neg. free water clearance, whereas I (15 mg/kg, i.v.) administration to hydropenic dogs caused a natriuresis and a diuresis. I resembled hydrochlorothiazide in the pattern of electrolyte response, the maximum natriuresis obtained, the comparable chloruresis, the modest kaliuresis, the prolonged duration of activity and natriuresis in the alkalotic and acidotic dog but differed from hydrochlorothiazide in being uricosuric in the dog. p-Aminohippurate (PAH) inhibited the renal secretion of I, and I inhibited renal PAH secretion. Apparently, the secretion of I is an active process and the site of the natriuretic activity of I is within the lumen of the renal tubule.
Postgraduate Medical Journal, Supplement published new progress about Biological transport. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Safety of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem