Lewis, D. F. V. published the artcileMolecular modeling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily, HPLC of Formula: 40180-04-9, the main research area is CYP2C subfamily enzyme mol modeling; cytochrome P450 2C subfamily mol modeling.
The results of mol. modeling of human CYP2C isoenzymes, CYP2C9 and CYP2C19, are reported based on an alignment with a bacterial form of the enzyme, CYP102. The three-dimensional structures of the CYP2C enzymes are consistent with known exptl. evidence from site-directed mutagenesis, antibody recognition and regiospecificity of substrate metabolism The variations in substrate specificity between CYP2C9 and CYP2CI9 can be rationalized in terms of single amino acid residue changes within the putative active site region, of which I99H appears to be the most significant.
Xenobiotica published new progress about Electrostatic force. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem