David, C. published the artcileSubstrate specificity of the luminal sodium-dependent sulfate transport system in the proximal renal tubule as compared to the contraluminal sulfate exchange system, COA of Formula: C13H8Cl2O4S, the main research area is sulfate transporter specificity kidney proximal tubule.
The efflux of [35S]sulfate from the lumen of the proximal renal tubule into tubular cells of rats was measured by the stop-flow tubular-lumen microperfusion technique. The transport parameters obtained and the apparent Ki values of competing substrates were compared with those of the contraluminal influx of [35S]-sulfate from the interstitium into tubular cells. For the luminal (l) sulfate efflux a Km(l, SO42-) of 0.8 mmol/L and a Jmax(l, SO42-) of 0.2 pmol s-1 cm-1 were found. The corresponding contraluminal (cl) values were Km(cl,SO42-) 2.5 mmol/L and Jmax(cl,SO42-) 1.2 pmol s-1 cm-1. Omission of Na+ from the perfusates reduced the luminal efflux of sulfate by 83%, while the contraluminal influx of sulfate was not changed. The most effective inhibitors of both sulfate transport systems are 8-anilino-1-naphthalenesulfonate, orange G, and H2-DIDS. The data indicate that the Na+-dependent luminal and the Na+-independent contraluminal sulfate transport systems accommodate a similar spectrum of anionic substrates, whereby the inhibitory potency against the luminal Na+-dependent sulfate transport system is identical or smaller than against the contraluminal transporter.
Pfluegers Archiv published new progress about Biological efflux. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, COA of Formula: C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem