Cusi, Daniele published the artcileThe effect of tienilic acid on sodium(1+) and potassium(1+) transport in human red cells, HPLC of Formula: 40180-04-9, the main research area is tienilate sodium potassium erythrocyte.
The effect of tienilic acid (I) [40180-04-9] and other antihypertensive drugs with diuretic properties on Na+ and K+ transport in human red cells was investigated. I is a less efficient inhibitor of erythrocyte Na+, K+ cotransport than furosemide [54-31-9], as well as being a weaker diuretic. In addition, the thiazides and K+-sparing diuretics do not inhibit the Na+,K+-cotransport system. Under conditions in which the erythrocytes have all of their saturable Na+ and K+ transport systems blocked, the addition of I increases K+ permeability. This effect shows saturation kinetics with the increase in the internal K+ concentration and could not be blocked by specific inhibitors of K+ channels. Thus, I may affect the opening of transient or permanent K+ channels.
Molecular Pharmacology published new progress about Antihypertensives. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem