Croft, Mary Ann published the artcileEffect of ticrynafen on aqueous humor dynamics in monkeys, Quality Control of 40180-04-9, the main research area is ticrynafen aqueous humor glaucoma.
Objective: To determine the effect of ticrynafen, a non-sulfhydryl-reactive compound similar to ethacrynic acid, on outflow facility in normotensive monkey eyes and on intraocular pressure (IOP) in monkey eyes with laser-induced glaucoma. Methods: In normotensive eyes, facility (perfusion) was measured shortly before and after bolus or exchange intracameral infusion of ticrynafen or vehicle in opposite eyes, and 3.5 to 4.5 h after 5 days of twice-daily 2% ticrynafen or vehicle ointment. In glaucomatous eyes, baseline and vehicle diurnal IOP curves were established, 2% ticrynafen ointment was given twice daily for 5 days, and IOP was measured immediately before and 0.5 to 6 h after each morning treatment. Results: In normotensive eyes, exchange 2-mL infusion of 0.2-, 1-, or 4-mmol/L ticrynafen increased facility by 33% ± 6% (mean ± SEM), 73% ± 18%, and 60% ± 11%, resp. Day 5 posttreatment facility was higher in the ticrynafen group than in controls by 28% ± 9%. In glaucomatous eyes, maximum IOP decline, from approx. 35 mm Hg, was 7.5 ± 2.0 mm Hg on day 4 and 9.8 ± 2.4 mm Hg on day 5 of twice-daily ticrynafen treatment. Conclusion: The facility-increasing, IOP-lowering action of ticrynafen, ethacrynic acid, and derivatives may not depend entirely on sulfhydryl reactivity. Clin. Relevance: Whether such drugs as ethacrynic acid and ticrynafen prove valuable for glaucoma therapy, at the least they are useful probes to study aqueous outflow mechanisms.
Archives of Ophthalmology (Chicago) published new progress about Antiglaucoma agents. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Quality Control of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem