Ames, Richard P. published the artcileAntihypertensive therapy and the risk of coronary heart disease, Name: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is antihypertensive therapy heart disease health; health hazard antihypertensive.
Diuretic drugs, when used in the treatment of hypertension in patients caused an increase in the serum concentration of total cholesterol and triglycerides. High d. lipoprotein (HDL) cholesterol remains stable with thiazide-type diuretic drugs. Treatment with furosemide [54-31-9], spironolactone [52-01-7], reserpine [50-55-5], and methyldopa [555-30-6] does not affect serum total cholesterol or triglyceride concentrations However, methyldopa decreases HDL cholesterol, and furosemide increases the ratio of total to HDL cholesterol. When reserpine, methyldopa, or β-blocking drugs are added to diuretic therapy, triglyceride increases and HDL cholesterol decreases. The mechanism of the lipid-lipoprotein alterations is unknown, but the changes correlate with changes in glycoHb and serum glucose noted during diuretic-based therapy. The changes in total cholesterol and HDL cholesterol caused by some antihypertensive agents counterbalance the benefits on the development of coronary heart disease (CHD) expected from the control of blood pressure. Thus, treatment regimens with a more favorable influence on serum lipids may be crucial to better control of CHD. Apparently therapy which does not disturb glucose metabolism is likely to be free of lipid effect, and, therefore, would qualify as preferred therapy for hypertension.
Journal of Cardiovascular Pharmacology published new progress about Antihypertensives. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Name: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem