Almohaywi, Basmah published the artcileDihydropyrrolones as bacterial quorum sensing inhibitors, Safety of 3-Acetylthiophene, the main research area is dihydropyyrolone preparation bacterial quorum sensing inhibitor SAR docking; Biofilm inhibition; Dihydropyrrolone; P. aeruginosa; Quorum sensing.
A range of dihydropyrrolone (DHP) analogs were synthesized via the lactone-lactam conversion of lactone intermediates. The synthesized compounds were tested for their ability to inhibit QS, biofilm formation and bacterial growth of Pseudomonas aeruginosa. The compounds were also docked into a LasR crystal structure to rationalize the observed structure-activity relationships. The most active compound identified in this study was 4-(4-bromophenyl)-5-methylene-1,5-dihydro-2H-pyrrol-2-one which showed 63.1% QS inhibition of at 31.25 μM and 60% biofilm reduction at 250 μM with only moderate toxicity towards bacterial cell growth.
Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem