Xu, Jun published the artcileA combination of heterogeneous catalysis and photocatalysis for the olefination of quinoxalin-2(1H)-ones with ketones in water: a green and efficient route to (Z)-enaminones, Safety of 3-Acetylthiophene, the main research area is enaminone quinoxalinone acylmethylene preparation diastereoselective green chem; quinoxalinone diastereoselective photochem olefination ketone.
Herein, a novel aqueous reaction for the olefination of quinoxalin-2(1H)-ones I (R1 = H, 5-Me, 6-OMe, 6,7-Cl2, etc.; R2 = H, Me, cyclohexylmethyl, allyl, Ph, 2,6-F2C6H3CH2, etc.) with ketones R3C(O)CH2R4 [R3 = Me, cyclopropyl, Ph, 3-thienyl, etc., R4 = H; R3R4 = (CH2)3, CH(cyclopentyl)CH2CH2] through a combinational strategy is described. This reaction features very mild conditions using a simple and cheap catalyst for the synthesis of (Z)-enaminones II in moderate-to-good yields. Such a methodol. successfully combines the heterogeneous Mannich reaction with photocatalysis, and provides a green and practical approach for the synthesis of potentially bioactive (Z)-enaminones with a 3,4-dihydroquinoxalin-2(1H)-one skeleton.
Green Chemistry published new progress about Diastereoselective synthesis. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem