Su, Jianke published the artcileDifluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines, Name: 3-Acetylthiophene, the main research area is vinylaniline difluorocarbene chemoselective cycloaddition; fluoroindole preparation.
Herein, an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluoroindoles were accessed with high efficiency and chemoselectivity was reported. Instead of starting from indole skeletons, in this strategy constructed indole scaffolds alongside the incorporation of fluorine atom on C2 position in a formal [4+1] cyclization from readily accessible ortho-vinylanilines and difluorocarbene. In this protocol, com. accessible halodifluoroalkylative reagents provide one carbon and one fluorine atom by cleaving one C-N tertiary bond and forming one C-N bond and one C-C double bond with ortho-vinylanilines. Downstream transformations on 2-fluoroindoles led to various valuable bioactive mols. which demonstrated significant synthetic advantages over previous reports. And mechanistic studies suggest that the reaction undergoes a cascade difluorocarbene-trapping and intramol. Michael addition reaction followed by Csp3-F bond cleavage.
Nature Communications published new progress about [4+1] Cycloaddition reaction (chemoselective). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem