Nicholson, Kieran published the artcileA Boron-catalyzed, Diastereo- and Enantioselective Allylation of Ketones with Allenes, Recommanded Product: 3-Acetylthiophene, the main research area is homoallylic alc preparation diastereoselective regioselective enantioselective mechanistic study; allene ketone allylation boron catalyst.
Here, a boron-catalyzed allylation of ketones R1C(O)R2 (R1 = Ph, furan-2-yl, benzodioxol-5-yl, etc.; R2 = Me, 4-fluorophenyl) and 1-indanone with allenes R3C(R4)=C=CH2 [R3 = cyclohexyl, phenylethyl, Me; R4 = H, Me; R3R4 = -(CH2)5-] is presented. Excellent yield, regioselectivity and diastereoselectivity were found across functionalized allylic alcs. R(R1)C(OH)C(R3)(R4)CH=CH2 and 1-(3-cyclohexylprop-1-ene)indanol. The reaction was further developed to accommodate an enantioenriched boron catalyst and thus gave asym. ketone allylation in good yield allylic alcs., diastereoselectivity and enantioselectivity. Mechanistic studies supported a hydroboration-allylation-transborylation pathway.
ACS Catalysis published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem