Chen, Lu published the artcileA modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation, Name: 3-Acetylthiophene, the main research area is allyl alc preparation diastereoselective chemoselective; vinylethylene carbonate preparation carboxylic acid allylation rhodium catalyst.
An Rh(III)-catalyzed native carboxylic acid-directed and solvent-free C-H activation allylation with high stereoselectivity and chemoselectivity is achieved. The generated poly-substituted allylic alc., e.g., I as a multifunctional and biomimetic building block is crucial for the synthesis of (Z)-allylic-supported macrolides, e.g., II. Moreover, the unique allylic-supported macrolides significantly potentiate the sensitivity of tumor cells to cytotoxic agents such as vinorelbine and docetaxel by reversing p170-glycoprotein-mediated MDR.
Nature Communications published new progress about Allylation catalysts, stereoselective (chemoselective). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem