Zhao, Peng’s team published research in Organic Letters in 2019-04-19 | CAS: 1468-83-3

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, COA of Formula: C6H6OS.

Zhao, Peng published the artcileDirect Synthesis of 2,3-Diaroyl Quinolines and Pyridazino[4,5-b]quinolines via an I2-Promoted One-Pot Multicomponent Reaction, COA of Formula: C6H6OS, the main research area is pyridazino diaroyl quinoline preparation iodine enaminone ketone aryl amine.

The first synthesis of 2,3-diaroyl quinolines via a formal [3 + 2 + 1] cycloaddition of enaminones, aryl Me ketones, and aryl amines is disclosed. This reaction efficiently affords a 1,4-dicarbonyl scaffold, which is a useful building block for constructing complex fused heterocycles. Furthermore, the 1,4-dicarbonyl scaffold was used directly to prepare pyridazino[4,5-b]quinoline skeletons in one-pot.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, COA of Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Tamuli, Kashyap J.’s team published research in ChemistrySelect in 2020 | CAS: 1468-83-3

ChemistrySelect published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Tamuli, Kashyap J. published the artcileRecyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5-Benzodiazepine Derivatives at Room Temperature, Synthetic Route of 1468-83-3, the main research area is benzodiazepine green preparation; phenylenediamine ketone cyclocondensation itaconic acid catalyst.

Herein, a water-mediated and metal-free mild protocol was described for the synthesis of 1,5-benzodiazepine derivatives I [R = i-Pr, Ph, 3-thienyl, etc.; R1 = H, 7-Me, 8-Me, 7-Cl, 8-Cl] via cyclocondensation reaction of o-phenylenediamines and ketones by using biodegradable naturally occurring itaconic acid (20 mol%) in 30 min with excellent yields. Major advantages of this method were reusable catalyst, metal free, toxic solvent free, tedious work-up free, no further purifications with column chromatog. and short reaction time.

ChemistrySelect published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Wang, Li-Sheng’s team published research in Organic Letters in 2022-06-24 | CAS: 1468-83-3

Organic Letters published new progress about Aralkyl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Wang, Li-Sheng published the artcileIodine-Mediated Multicomponent Cascade Cyclization and Sulfenylation/Selenation: Synthesis of Imidazo[2,1-a]isoquinoline Derivatives, Recommanded Product: 3-Acetylthiophene, the main research area is aryl methyl ketone isoquinolinamine sodium arylsulfinate multicomponent cyclization sulfenylation; isoquinolinamine aryl methyl ketone diphenyldiselane multicomponent cascade cyclization selenation; imidazo isoquinoline preparation green chem iodine mediator.

A novel multicomponent cascade cyclization and sulfenylation/selenation using aryl Me ketones, isoquinolin-1-amine, and sodium arylsulfinates/1,2-diphenyldiselane to synthesize imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C-N bonds and one C-S/C-Se bond has been reported. This multicomponent reaction realizes simultaneous C(sp3)-H amination and sulfenylation/selenation, avoiding complicated prior substrate preparation This process has simple operating conditions and good substrate compatibility.

Organic Letters published new progress about Aralkyl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Zhang, Ting-Yu’s team published research in Organic Letters in 2017-04-07 | CAS: 19156-54-8

Organic Letters published new progress about Alkynes, arynes Role: RCT (Reactant), RACT (Reactant or Reagent). 19156-54-8 belongs to class benzothiophene, name is 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, and the molecular formula is C9H10O2S, Recommanded Product: 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid.

Zhang, Ting-Yu published the artcileCopper-Catalyzed Selective ortho-C-H/N-H Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids, Recommanded Product: 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, the main research area is copper catalyst annulation benzamide aryne; phenanthridinone alkaloid preparation.

An efficient and convenient copper-catalyzed method was developed to achieve direct ortho-C-H/N-H annulation to synthesize phenanthridinones with arynes. This method highlights an emerging strategy to transform inert C-H bonds into versatile functional groups in organic synthesis and provides a new way to synthesize phenanthridinone alkaloids efficiently.

Organic Letters published new progress about Alkynes, arynes Role: RCT (Reactant), RACT (Reactant or Reagent). 19156-54-8 belongs to class benzothiophene, name is 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, and the molecular formula is C9H10O2S, Recommanded Product: 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Hsiao, Ya-Wen’s team published research in Journal of Chemical Information and Modeling in 2012-03-26 | CAS: 40180-04-9

Journal of Chemical Information and Modeling published new progress about Aflatoxins Role: PKT (Pharmacokinetics), BIOL (Biological Study). 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.

Hsiao, Ya-Wen published the artcileA Pragmatic Approach Using First-Principle Methods to Address Site of Metabolism with Implications for Reactive Metabolite Formation, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is drug metabolism reactive metabolite formation.

A majority of xenobiotics are metabolized by cytochrome P 450 (CYP) enzymes. The discovery of drug candidates with low propensity to form reactive metabolites and low clearance can be facilitated by understanding CYP-mediated xenobiotic metabolism Being able to predict the sites where reactive metabolites form is beneficial in drug design to produce drug candidates free of reactive metabolite issues. Herein, we report a pragmatic protocol using first-principle d. functional theory (DFT) calculations for predicting sites of epoxidation and hydroxylation of aromatic substrates mediated by CYP. The method is based on the relative stabilities of the CYP-substrate intermediates or the substrate epoxides. Consequently, it concerns mainly the electronic reactivity of the substrates. Comparing to the exptl. findings, the presented protocol gave excellent first-ranked epoxidation site predictions of 83%, and when the test was extended to CYP-mediated sites of aromatic hydroxylation, satisfactory results were also obtained (73%). This indicates that our assumptions are valid and also implies that the intrinsic reactivities of the substrates are in general more important than their binding poses in proteins, although the protocol may benefit from the addition of docking information.

Journal of Chemical Information and Modeling published new progress about Aflatoxins Role: PKT (Pharmacokinetics), BIOL (Biological Study). 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Cao, Fei’s team published research in New Journal of Chemistry in 2021 | CAS: 1468-83-3

New Journal of Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Cao, Fei published the artcileThe preparation of a Co@C3N4 catalyst and applications in the synthesis of quinolines from 2-aminobenzyl alcohols with ketones, Category: benzothiophene, the main research area is cobalt doped carbon nitride catalyst quinoline synthesis aminobenzenemethanol ketone.

An unsym. diphenylphosphino-pyridinyl-triazole ligand was synthesized and characterized through IR, NMR and MS and the corresponding earth-abundant metal complex (cobalt) was prepared Considering energy consumption and environmental friendliness, it is necessary to turn this diphenylphosphino-pyridinyl-triazole cobalt complex into a recyclable catalyst, which could easily be reused. Therefore, a heterogeneous catalyst was synthesized through Co-doping of C3N4, and the Co-nanoparticles on C3N4 revealed high catalytic activity for the synthesis of quinolines with good recovery performance.

New Journal of Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Vigneswaran, Vipulan’s team published research in Organometallics in 2019-11-25 | CAS: 1468-83-3

Organometallics published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Vigneswaran, Vipulan published the artcileBeta-amino phosphine Mn catalysts for 1,4-transfer hydrogenation of chalcones and allylic alcohol isomerization, Safety of 3-Acetylthiophene, the main research area is amino phosphine Mn catalyst preparation transfer hydrogenation chalcone isomerization; transfer hydrogenation chalcone allylic alc isomerization.

Mn complexes with amino acid derived PN ligands were used in the catalytic transfer hydrogenation (TH) of ketone and chalcone substrates in 2-propanol with mild heating. Moreover, chalcones are reduced selectively to the saturated ketone at short times and can be fully converted to the alc. when reactions are prolonged. The mechanism of chalcone reduction was briefly considered. Allylic alcs. are not reactive in 2-propanol, but quant. isomerization occurs in toluene. Thus, we suspect that the allylic alcs. are dehydrogenated and the resulting ketone is formed through a direct 1,4-hydrogenation of the chalcone. Finally, several other related ligands that have been used in Mn-based TH reactions were explored to test the viability of ligand design in favoring chemoselectivity. The β-amino phosphine ligands proved most effective in this regard. Mn complexes with amino acid-derived PN ligands were used to enact catalytic transfer hydrogenation (TH) of ketone and chalcone substrates in 2-proponal with mild heating. Moreover, chalcones are reduced selectively to the saturated ketone at short times and can be fully converted to the alc. under prolonged reactions. The mechanism of chalcone reduction was briefly considered. Allylic alcs. are not reactive in 2-proponal, but quant. isomerization occurs in toluene. Thus, we suspect that the allylic alcs. are dehydrogenated and the resulting ketone is formed through a direct 1,4-hydrogenation of the chalcone. Finally, several other related ligands that have been used in Mn-based TH reactions were explored to test the viability of ligand design in favoring chemoselectivity. The beta-amino phosphine ligands proved most effective in this regard.

Organometallics published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Laha, Joydev K.’s team published research in New Journal of Chemistry in 2021 | CAS: 1468-83-3

New Journal of Chemistry published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Laha, Joydev K. published the artcileMinisci aroylation of N-heterocycles using choline persulfate in water under mild conditions, Safety of 3-Acetylthiophene, the main research area is acyl isoquinoline indole preparation green chem choline persulfate mediated; isoquinoline indoel arylglyoxylic acid Minisci aroylation choline persulfate.

Metal persulfate mediated thermal oxidative organic transformations invariably require a higher temperature and frequently use an organic solvent. The objective of this work was to develop persulfate mediated oxidative transformations that can be performed nearly at room temperature using water as a solvent. This report describes modified Minisci aroylation of isoquinolines with arylglyoxylic acids using choline persulfate and its pre-composition (choline acetate and K2S2O8) in water at 40°C. A few other nitrogen heterocycles were also utilized affording various aroylated products in good to excellent yields. Unlike metal persulfate that could produce metal salt byproducts, a key feature of the chem. reported herein includes the use of environmentally benign choline persulfate containing biodegradable choline as a counter-cation, the Minisci reaction demonstrated at 40°C in water as the only solvent, and unconventional activation of persulfate.

New Journal of Chemistry published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem