Day: November 14, 2022

Jiang, Jingjing published the artcileThree-component synthesis of 1,4-benzothiazines via iodide-catalyzed aerobic C-H sulfuration with elemental sulfur, Synthetic Route of 1468-83-3, the main research area is benzothiazine preparation green chem diastereoselective; acetophenone aniline sulfur three component sulfuration iodide catalyst.

Herein, iodide-catalyzed aerobic synthesis of 1,4-benzothiazines via functionalization of multiple C-H bonds with elemental sulfur is described. Beyond the well-established thiazole formation from elemental sulfur, this method provides the first access to the corresponding six-membered N,S-heterocyclic products via direct functionalization of multiple C-H bonds. Hence, 1,4-benzothiazine products were generated in satisfactory yields with a range of compatible functionalities.

Organic & Biomolecular Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhao, Peng published the artcileIodine-Promoted Multicomponent Synthesis of 2,4-Diamino-1,3,5-triazines, Quality Control of 1468-83-3, the main research area is methyl ketone cyanamide arylamine cyclization iodine multicomponent amination; diamino triazine preparation.

A novel and efficient multicomponent cyclization of Me ketones, cyanamides, and arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation of four C-N bonds is reported. This multicomponent reaction is characterized by the employment of two mols. of cyanamide for double C(sp3)-H amination of Me ketones, avoiding complicated preparation of substrates and expanding the substrate scope. Furthermore, this multicomponent cyclization strategy provides a new approach for generating diverse 2,4-diamino-1,3,5-triazines with a broad substrate scope under mild conditions.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Dattatri published the artcileCu-Catalyzed tandem cyclization and coupling of enynones with enaminones for multisubstituted furans & furano-pyrroles, Recommanded Product: 3-Acetylthiophene, the main research area is furan furano pyrrole preparation; enynone enaminone coupling tandem cyclization copper.

A synthetic strategy that efficiently constructs complex mol. diversity in a few steps will always be embraced by organic chemists. Here, authors report a cascade reaction of enynones with enaminones via carbene insertion and aryl migration to engineer distinctive multisubstituted furans with an all-carbon quaternary center, and could extend the protocol in the same pot towards furano-pyrrole bis-heterocycles. Heterogeneity of this protocol was proved with the upshot of divergent chem. space under a relatively mild reaction environment.

Organic & Biomolecular Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chan, Chieh-Kai published the artcileAcid-controlled multicomponent selective synthesis of 2,4,6-triaryl pyridines and pyrimidines by using hexamethyldisilazane as a nitrogen source under microwave irradiation, HPLC of Formula: 1468-83-3, the main research area is triaryl pyridine pyrimidine preparation; acetophenone benzaldehyde microwave irradiation multi component reaction.

An efficient and general protocol for the synthesis of functionalized 2,4,6-triaryl pyridines and pyrimidines was developed from com. available aromatic ketones, aldehydes and hexamethyldisilazane (HMDS) as a nitrogen source under microwave irradiation In this multicomponent synthetic route, Lewis acids play an important role in selectively synthesizing six-membered heterocycles, including pyridines (1N) and pyrimidines (2N), by involving [2 + 1 + 2 + 1] or [2 + 1 + 1 + 1 + 1] annulated processes.

RSC Advances published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Dolan, Martin A. published the artcileCatalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation, Formula: C6H6OS, the main research area is short peptide catalytic nanoassembly enantioselective transfer hydrogenation; ATH; catalysis; enantioselective; micelle; peptide; self-assembly; vesicle.

Self-assembly enables formation of incredibly diverse supramol. structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramol., vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).

ACS Nano published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Passera, Alessandro published the artcileThe Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege, Name: 3-Acetylthiophene, the main research area is chiral aryl alkyl alc synthesis asym transfer hydrogenation acetophenone; ligand designed manganese catalyzed asym transfer hydrogenation acetophenone; alcohols; asymmetric catalysis; hydrogenation; ligand design; manganese.

The bis(carbonyl) manganese(I) complex [Mn(CO)2(ligand)]Br with a chiral (NH)2P2 macrocyclic ligand catalyzes the asym. transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcs. in high yields (up to >99%) and with excellent enantioselectivities (90-99% ee). A stereochem. model based on attractive CH-π interactions is proposed.

Angewandte Chemie, International Edition published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Das, Siuli published the artcileMetal-Ligand Cooperative Approach To Achieve Dehydrogenative Functionalization of Alcohols to Quinolines and Quinazolin-4(3H)-ones under Mild Aerobic Conditions, Quality Control of 1468-83-3, the main research area is quinoline preparation cooperative metal ligand catalyzed dehydrogenative functionalization alc; quinazolinone preparation cooperative metal ligand catalyzed dehydrogenative functionalization alc.

A simple metal-ligand cooperative approach for the dehydrogenative functionalization of alcs. to various substituted quinolines and quinazolin-4(3H)-ones under relatively mild reaction conditions (≤90 °C) is reported. Simple and easy-to-prepare air-stable Cu(II) complexes featuring redox-active azo-aromatic scaffolds, 2-arylazo-(1,10-phenanthroline) (L1,2), are used as catalyst. A wide variety of substituted quinolines and quinazolin-4(3H)-ones were synthesized in moderate to good isolated yields via dehydrogenative coupling reactions of various inexpensive and easily available starting materials under aerobic conditions. A few control experiments and deuterium labeling studies were carried out to understand the mechanism of the dehydrogenative coupling reactions, which indicate that both copper and the coordinated azo-aromatic ligand participate in a cooperative manner during the catalytic cycle.

Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chitrakar, Ravi published the artcileDesign, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles, Recommanded Product: 3-Acetylthiophene, the main research area is arylsulfenyl benzimadazole preparation antitumor SAR; Anticancer agents; Chemotherapeutic agents; Human cancer cell lines; Metabolically stable; Sulfinylated Imidazo[1,2-a]pyridine.

The design, synthesis and study of anticancer properties of sulfenylated 2-phenylimidazo[1,2-a]pyridines I [R = H, Me, Cl, Ph; Ar = (E)-styryl, 4-methylsulfanylphenyl, 1-naphthyl, etc.; Ar1 = Ph, 4-ClPh, 1-naphthyl] and their analogs were prepared A set of twenty sulfenylated imidazo[1, 2-a]pyridine derivatives I were synthesized. Whereby elusive amendmented to the imidazo[1,2-a]pyridine motif confer dramatic changes in functional affinity of a novel action to modulate anticancer activity in seven different human cancer cell lines i.e.: MDA MB 231 (breast), HepG2 (liver), Hela (cervical), A549 (lung), U87MG (glioblastoma), SKMEL-28 (skin melanoma) and DU-145 (prostate) by employing MTT assay. Among the series, compounds I [R = H, Ar = 1-naphthyl, Ar1 = Ph; R = H, Ar = (E)-styryl, Ar1 = Ph; R = H, Ar = 4-methylsulfanylphenyl, Ar1 = Ph] showed potent activity towards human liver cancer cells HepG2. Cell cycle anal. results revealed that these compounds I [R = H, Ar = 1-naphthyl, Ar1 = Ph; R = H, Ar = (E)-styryl, Ar1 = Ph; R = H, Ar = 4-methylsulfanylphenyl, Ar1 = Ph] arrested the cell cycle at G2/M phase and induced apoptosis in human liver cancer cells HepG2. It was further confirmed by Hoechst staining, Measurement of mitochondrial membrane potential (ΔΨm) and Annexin V-FITC assay.

Bioorganic & Medicinal Chemistry Letters published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Maji, Ankur published the artcileWell-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines, Formula: C6H6OS, the main research area is quinoline pyrrole pyridine preparation density functional theory; amino alc ketone manganese complex catalyst.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Gupta, Shivangi published the artcileCuO NPs catalyzed synthesis of quinolines, pyridines, and pyrroles via dehydrogenative coupling strategy, Application In Synthesis of 1468-83-3, the main research area is hydroxymethyl aniline ketone copper nanocatalyst oxidative coupling reaction; quinoline preparation; hydroxypropanamine ketone copper nanocatalyst oxidative coupling reaction; pyridine preparation; hydroxyethanamine ketone copper nanocatalyst oxidative coupling reaction; pyrrole preparation.

Copper oxide nanoparticles catalyzed efficient synthesis of quinolines, pyridines, and pyrroles via alc. dehydrogenative coupling strategy are reported. Employing this catalytic system, various functionalized quinolines, pyridines, and pyrroles were synthesized efficiently from different amino alcs. with a diverse range of ketones. A number of control experiments were performed to shed light on the mechanism. This catalyst was recycled up to 6th run and notably, no significant loss was observed in its catalytic activity.

Journal of Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem