Day: November 14, 2022

Zhang, Bing published the artcileRhodium-Catalyzed Regiodivergent Synthesis of Alkylboronates via Deoxygenative Hydroboration of Aryl Ketones: Mechanism and Origin of Selectivities, Recommanded Product: 3-Acetylthiophene, the main research area is rhodium catalyzed regiodivergent regioselective hydroboration aryl ketone; branched alkylboronate triboronate preparation; mol structure calculation rhodium catalyzed regioselective hydroboration aryl ketone.

Here, authors report an efficient rhodium-catalyzed deoxygenative borylation of ketones to synthesize alkylboronates, in which the regioselectivity can be switched by the choice of the ligand. The linear alkylboronates were obtained exclusively in the presence of P(nBu)3, and PPh2Me favored the formation of branched alkylboronates. The protocol also allows access to 1,1,2-triboronates from the readily available ketones. Mechanistic studies suggest that this Rh-catalyzed deoxygenative borylation of ketones goes through an alkene intermediate, which undergoes regiodivergent hydroboration to afford linear and branched alkylboronates. The different steric effects of PPh2Me and P(nBu)3 were responsible for product selectivity by d. functional theory calculations The alkene intermediate can alternatively undergo sequential dehydrogenative borylation and hydroboration to deliver the triboronates.

ACS Catalysis published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cai, Qun published the artcileI2-promoted tandem cyclization to synthesize polysubstituted pyrano[3,2-c]chromene-2,5-diones, Recommanded Product: 3-Acetylthiophene, the main research area is aryl ethanone hydroxycoumarin iodine tandem iodination Kornblum oxidation heterocyclization; hydroxybenzoyl aroyl pyranochromene dione preparation.

An efficient and convenient method for the synthesis of various substituted pyrano[3,2-c]chromene-2,5-diones was developed via the I2-promoted tandem cyclization of com. available aryl Me ketones and 4-hydroxycoumarins. Preliminary mechanism studies indicated that the reaction involved a consecutive iodination/Kornblum oxidation/annulation process. HI produced in the I2-DMSO system acted as an important promoter, accelerating the annulation protocol.

Tetrahedron published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chen, Jing published the artcileSelectfluor-promoted Synthesis of 2,4- and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF, Synthetic Route of 1468-83-3, the main research area is diarylpyridine preparation regioselective; aromatic ketone ammonium acetate DMF condensation cyclization Selectfluor.

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Sym. pyridines were obtained selectively when non-Me ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process.

ChemistrySelect published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chen, Shanping published the artcileThree-Component Cascade Synthesis of Carbazoles through [1s,6s] Sigmatropic Shift under Metal-Free Conditions, Product Details of C6H6OS, the main research area is carbazole derivative preparation; indole arylketone methacrylate three component reaction sigmatropic shift.

A novel method was developed for the synthesis of substituted carbazoles from com. available starting materials under metal-free conditions. This strategy involves a [1s,6s] sigmatropic shift step and introduces an electron-withdrawing ester substituent at the C2 position of the carbazole ring. The present protocol afforded the desired carbazole derivatives with good regioselectivity and well functional group tolerance. DFT calculations were carried out to support the reaction pathway.

Journal of Organic Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Hu, Wenkang published the artcileThe synthesis of methyl triazole-4-carboxylate gold(I) complex and application on allene synthesis and alkyne hydration, SDS of cas: 1468-83-3, the main research area is gold methyl triazolylcarboxylate complex preparation hydration catalyst; crystal structure gold methyl triazolylcarboxylate complex.

The Me 1H-1,2,3-triazole-4-carboxylate containing a strong electron-withdrawing group was developed and applied as a ligand for gold(I) cations. The resulting ester-triazole gold(I) complex was studied for its efficiency in catalyzing allene synthesis and alkyne hydration, in which an excellent catalytic efficiency was observed with low catalyst loadings.

Inorganic Chemistry Communications published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ning, Yongquan published the artcileAg-Catalyzed Insertion of Alkynyl Carbenes into C-C Bonds of β-Ketocarbonyls: A Formal C(sp2) Insertion, Formula: C6H6OS, the main research area is allenyl diketone preparation; diketone insertion alkynyl carbene alkynyl nosyl hydrazone silver catalyst.

Herein, a silver-catalyzed alkynyl carbene insertion into β-ketocarbonyls I (R1 = R3 = Me, Et, Ph, 4-t-BuC6H4, 3-thienyl, etc., R2 = H; R1 = Ph, R2 = H, R3 = Me, 4-F3CC6H4; R1 = R3 = Me, R2 = Me, Et, PhCH2; etc.) using alkynyl N-nosylhydrazones II [R4 = cyclopropyl, Cl(CH2)3, Ph, 3-MeOC6H4, 3,5-Cl2C6H3, 2-naphthyl, 1-cyclohexen-1-yl, etc.; Ns = 2-nitrophenylsulfonyl] as alkynyl carbene precursors, which provides access to trisubstituted allenyl ketones III, is reported. This reaction represents the first example of an alkynyl carbene insertion into a C-C σ bond, affording products homologated with an sp2 carbon center. The products are useful substrates for further transformations. Exptl. investigations and theor. calculations suggest the reaction proceeds through a stepwise enol cyclopropanation/retro-aldol pathway.

Organic Letters published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Majhi, Jadab published the artcileDynamic Kinetic Resolution of Alkenyl Cyanohydrins Derived from α,β-Unsaturated Aldehydes: Stereoselective Synthesis of E-Tetrasubstituted Olefins, Category: benzothiophene, the main research area is tetrasubstituted olefin stereoselective synthesis dynamic kinetic resolution alkenyl cyanohydrin; dynamic kinetic resolution alkenyl cyanohydrin unsaturated aldehyde.

A novel dynamic kinetic resolution (DKR) of tetrasubstituted alkenyl cyanohydrins prepared from the corresponding α,β-unsaturated aldehydes is described. The deprotonation of a geometrical mixture of tetrasubstituted alkenyl cyanohydrins with sodium diisopropylamide (NaDA) enables the equilibration of the E- and Z-olefins and the selective functionalization of former to selectively afford the E-adduct. Theor. studies indicate that the nature of the alkali metal cation is a critical component to lowering the barrier for interconversion between the two geometrical isomers, which provides the mechanistic basis for the DKR reaction. In addition, we demonstrate that the DKR reaction can be combined with a transition-metal-catalyzed allylic substitution to generate a stereodefined E-tetrasubstituted olefin and quaternary center in a single cross-coupling reaction.

Journal of the American Chemical Society published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Dana, Suman published the artcileRuthenium(II)-Catalyzed Regioselective C-H Olefination of Aromatic Ketones and Amides with Allyl Sulfones, Recommanded Product: 3-Acetylthiophene, the main research area is aromatic ketone amide allyl sulfone olefination ruthenium catalyst.

A Ru(II)-catalyzed cross-dehydrogenative Heck-type olefination of arenes with allyl sulfones leveraging the assistance of weakly coordinating ketone and amide functional groups is reported. It features a distinct reactivity profile in comparison to other allylic congeners, where β-sulfonyl elimination was not detected. The ambiphilic nature of the allyl sulfone side chain has also been demonstrated through intramol. aza-Michael addition and aldol condensation. Mechanistic studies indicated the involvement of a reversible metalation step, where β-hydride elimination takes place selectively from the benzylic position.

Organic Letters published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Li, Meiqi published the artcileRoute to Chiral Tetrahydrofuran Acetals via Pd-Catalyzed Asymmetric Allylic Cycloaddition of Vinyl Epoxides with β-Keto Enol Ethers, Safety of 3-Acetylthiophene, the main research area is THF acetal preparation enantioselective diastereoselective; vinyl epoxide keto enol ether asym allylic cycloaddition palladium.

An efficient method for the synthesis of functionalized chiral THF (THF) acetals via Pd-catalyzed asym. allylic cycloaddition has been developed. With a palladium catalyst coordinated by a chiral phosphine ligand, the protocol is enabled to combine readily available vinyl epoxides and β-keto enol ethers to produce THF acetals bearing three stereocenters in a broad substrate scope with uniformly high levels of enantio- and diastereoselectivity.

Organic Letters published new progress about Acetals Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chen, Dongdong published the artcileDomino synthetic strategy for tetrahydrothiophene derivatives from 2-acetylfuran/2-acetylthiophene, benzaldehydes, and sulfur powder, COA of Formula: C6H6OS, the main research area is tetrahydrothiophene preparation diastereoselective; acetylfuran benzaldehyde sulfur domino; acetylthiophene benzaldehyde sulfur domino.

A domino reaction from 2-acetylfuran/2-acetylthiophene, benzaldehydes and sulfur powder was developed to synthesize a series of tetrahydrothiophene derivatives I [R = H, 4-F, 4-Ph, etc.; X = O,S]. The reaction proceeded well to construct five new bonds and a tetrahydrothiophene ring by one-pot. A possible mechanism was proposed, involving a stepwise of Aldol/double Michael addition/internal SN2 cascaded reaction with sulfur powder acts as a source of sulfur. This method was characterized by mild reaction conditions, com. available starting materials and transition-metal-free.

Arabian Journal of Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, COA of Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem