Nayak, Soukhyarani G. published the artcileNovel pyrazole-clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti-inflammatory agents, Product Details of C6H6OS, the main research area is pyrazolyl thiophene carbonitrile Schiff base preparation antibacterial antiinflammatory antitubercular; Gewald reaction; Schiff bases; anti-inflammatory; antimicrobial; antitubercular.
The aim of this study was to synthesize newer potent Schiff bases I (R = H, Cl; Ar = 4-fluorophenyl, 3-bromophenyl, 3-thienyl, etc.) by condensing 2-amino-5-(2,4-dichlorophenyl)thiophene-3-carbonitrile and 1,3-disubstituted-1H-pyrazole-4-carbaldehydes II, and to investigate their biol. activity. The compounds I were synthesized via Gewald synthesis and characterized by spectral data and elemental analyses. They were screened for their in vitro antibacterial and anti-inflammatory activities. The synthesized compounds I were also evaluated for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using the microplate Alamar Blue assay. Compounds I (R = H, Ar = 4-chlorophenyl; R = H, Ar = 4-fluorophenyl; R = H, Ar = 4-methoxyphenyl; R = H, Ar = 4-methylphenyl; R = Cl, Ar = 4-fluorophenyl; R = Cl, Ar = 4-methoxyphenyl; R = Cl, Ar = 4-methylphenyl) showed promising antibacterial activity. The interactions between the substituted pyrazoles and bovine protein showed promising anti-inflammatory activity. The exptl. results revealed compound I (R = H; Ar = Ph) as a promising antitubercular agent. Hemolytic assays confirmed that the compounds are nontoxic, with percentage hemolysis ranging from 3.6 to 20.1, at a concentration of 1 mg/mL. The results suggest that the pyrazole ring and the substitution pattern on the heterocyclic moiety I have an effect on the bioactivity.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem