Chitrakar, Ravi published the artcileDesign, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles, Recommanded Product: 3-Acetylthiophene, the main research area is arylsulfenyl benzimadazole preparation antitumor SAR; Anticancer agents; Chemotherapeutic agents; Human cancer cell lines; Metabolically stable; Sulfinylated Imidazo[1,2-a]pyridine.
The design, synthesis and study of anticancer properties of sulfenylated 2-phenylimidazo[1,2-a]pyridines I [R = H, Me, Cl, Ph; Ar = (E)-styryl, 4-methylsulfanylphenyl, 1-naphthyl, etc.; Ar1 = Ph, 4-ClPh, 1-naphthyl] and their analogs were prepared A set of twenty sulfenylated imidazo[1, 2-a]pyridine derivatives I were synthesized. Whereby elusive amendmented to the imidazo[1,2-a]pyridine motif confer dramatic changes in functional affinity of a novel action to modulate anticancer activity in seven different human cancer cell lines i.e.: MDA MB 231 (breast), HepG2 (liver), Hela (cervical), A549 (lung), U87MG (glioblastoma), SKMEL-28 (skin melanoma) and DU-145 (prostate) by employing MTT assay. Among the series, compounds I [R = H, Ar = 1-naphthyl, Ar1 = Ph; R = H, Ar = (E)-styryl, Ar1 = Ph; R = H, Ar = 4-methylsulfanylphenyl, Ar1 = Ph] showed potent activity towards human liver cancer cells HepG2. Cell cycle anal. results revealed that these compounds I [R = H, Ar = 1-naphthyl, Ar1 = Ph; R = H, Ar = (E)-styryl, Ar1 = Ph; R = H, Ar = 4-methylsulfanylphenyl, Ar1 = Ph] arrested the cell cycle at G2/M phase and induced apoptosis in human liver cancer cells HepG2. It was further confirmed by Hoechst staining, Measurement of mitochondrial membrane potential (ΔΨm) and Annexin V-FITC assay.
Bioorganic & Medicinal Chemistry Letters published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem