Zheng, Wei-Feng published the artcileTetrasubstituted allenes via the palladium-catalysed kinetic resolution of propargylic alcohols using a supporting ligand, Application of 3-Acetylthiophene, the main research area is allenoic acid preparation enantioselective; propargylic alc kinetic resolution carboxylation reaction palladium catalyst.
A straightforward catalytic asym. synthesis of tetrasubstituted 2,3-allenoic acids I (R1 = Bu, iso-Pr, 2-phenylethyl, etc.; R2 = Ph, thiophen-3-yl, cyclohexyl, etc.; R3 = Me, Et; R2R3 = 1,2,3,4-tetrahydronaphthalen-1-ylidene) from readily available racemic propargylic alcs. R1CCC(R2)(R3)(OH) has been reported. Enabled by the co-catalysis of palladium and a Bronsted acid in the presence of a com. available chiral ligand (DTBM-SEGphos) and an achiral monophosphine supporting ligand (PPh3), the kinetic resolution of propargylic alcs. proceeded efficiently in the presence of water and 1 atm CO, affording tetrasubstituted 2,3-allenoic acids in excellent enantioselectivity and atom economy with a good functional group compatibility. Performing a second kinetic resolution on the unreacted alc. gave access to the other enantiomer of the product. These allenes are precursors to compounds with quaternary carbon centers and other chiral tetrasubstituted allene building blocks, which are of great interest.
Nature Catalysis published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application of 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem