Zhang, Mengru published the artcileCopper-catalyzed [3+1] cyclization of cyclopropenes/diazo compounds and bromodifluoroacetamides: facile synthesis of α,α-difluoro-β-lactam derivatives, Application of 3-Acetylthiophene, the main research area is difluoro lactam preparation diastereoselective; cyclopropene bromodifluoroacetamide preparation cyclization copper catalyst; diazo compound bromodifluoroacetamide preparation cyclization copper catalyst.
A novel copper-catalyzed cyclization of cyclopropenes I (R1 = Ph, naphthalen-2-yl, thiophen-3-yl, etc.; R2 = Me, Ph, 4-fluorophenyl, etc.; R1R2 = 1,2,3,4-tetrahydronaphthalen-1-yl)/diazo compounds 3-R3C6H4C(=N2)C(O)OR4 (R3 = H, F, Cl; R4 = Me, Et, Bn) and bromodifluoroacetamides R5NHC(O)C(F2)Br (R5 = n-Pr, Ph, 3,4-dichlorophenyl, etc.), efficiently synthesizing a series of α,α-difluoro-β-lactams (E)-II and (E)-III in moderate to excellent yields under mild reaction conditions was developed. This reaction represents the first example of [3+1] cyclization for the synthesis of β-lactams utilizing a metal carbene intermediate as the C1 synthon.
Chemical Science published new progress about Cyclization catalysts, stereoselective (3+1). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application of 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem