Zhang, Guan published the artcileN2H4-H2O Enabled Umpolung Cyclization of o-Nitro Chalcones for the Construction of Quinoline N-Oxides, Application In Synthesis of 1468-83-3, the main research area is quinoline oxide green preparation; nitrochalcone hydrazine hydrate umpolung cyclization.
Umpolung was a unique strategy which converts the property of an atom into the opposite one. An efficient and general method for the construction of quinoline N-oxides I [R = Me, Ph, 2-pyridyl, etc.; R1 = 6-F, 6-Br, 6,7-di-OMe, etc.] via umpolung of carbonyl groups was developed from ortho-nitro chalcones and hydrazine in basic conditions. The strategy was transition-metal free and had good functional group tolerance, environmental friendliness, as well as mild reaction conditions with nitrogen gas as the byproduct.
Organic Letters published new progress about Cyclization. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem